ArticleSurgical case reports2025
Recent Treatment Options for Primary Colonic Leiomyosarcoma: A Case Report and a Review of the Literature.
Article in Surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrimary colonic leiomyosarcoma (LMS) accounts for only 0.12% of colonic malignancies. However, it is highly aggressive and associated with a poor prognosis. While radical surgical resection is considered the mainstay of treatment, the optimal surgical approach and the role of adjuvant chemotherapy remain unclear due to the small number of reported cases. CASE PRESENTATION: A 45-year-old, male patient presented with hematochezia. Colonoscopy revealed a 40-mm, type 1 tumor in the sigmoid colon. Immunohistochemical analysis of a biopsy specimen found atypical spindle cell proliferation, positivity for desmin and h-caldesmon, and negativity for CK AE1/AE3, indicating smooth muscle differentiation. Contrast-enhanced CT demonstrated a 40-mm, enhancing mass without a lymph node or distant metastasis. The patient underwent a laparoscopic sigmoidectomy with lymph node dissection. Pathological examination confirmed a 40 × 42 × 35 mm, French Federation of Cancer Centers (FNCLCC) grade 2 leiomyosarcoma with partial serosal exposure, negative margins, and no nodal involvement (0/42). Immunohistochemistry revealed positivity for α-SMA, desmin, h-caldesmon, and calponin, with a Ki-67 index of 60%-80%. Postoperatively, the patient received six cycles of adjuvant chemotherapy with doxorubicin and ifosfamide. A follow-up examination at 3 years and 6 months found no recurrence.
conclusionsThis report underscores the potential efficacy of minimally invasive surgery and adjuvant chemotherapy in some patients with primary colonic LMS, which in the present case was successfully managed with laparoscopic resection followed by adjuvant chemotherapy. More evidence is needed to establish a standard treatment strategy.
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