ArticleFrontiers in veterinary science2025
Alleviation effect of glycyrrhetinic acid on zearalenone-induced reproductive toxicity in replacement gilts.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: This study investigated whether glycyrrhetinic acid (GA) can alleviate the reproductive toxicity of Zearalenone (ZEN) in replacement gilts. Methods: Eighty Landrace × Yorkshire gilts were randomly assigned to four dietary groups: control (basal diet), ZEN (1 mg/kg), GA (400 mg/kg), and ZEN + GA (1 mg/kg ZEN + 400 mg/kg GA). Results: The onset of estrus advanced significantly in all treatment groups, with the GA and ZEN + GA groups showing the most pronounced changes. Puberty onset occurred earlier in the ZEN group and was further advanced by GA supplementation. ZEN exposure impaired uterine and ovarian development, while GA improved organ development and mitigated the abnormalities in the ZEN + GA group. Hormonal analysis revealed that ZEN reduced estradiol (E2) and luteinizing hormone (LH), whereas GA elevated all measured hormones. The ZEN + GA group showed a partial recovery in hormone levels, excluding E2. Histological examination of liver tissue in the ZEN group revealed focal hepatocellular necrosis and lymphocyte infiltration, which GA notably attenuated. ZEN upregulated 3α/3β/17β-hydroxysteroid dehydrogenase ( Discussion and conclusion: These findings suggest that GA can alleviate ZEN-induced reproductive toxicity via modulation of endocrine and hepatic metabolic pathways.
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