ReviewFrontiers in veterinary science2025
Age-related obesity and inflammaging in cats.
Review in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multi-target synergistic mechanisms of flavonoid compounds from traditional Chinese medicine in non-alcoholic fatty liver disease: insights for human and veterinary medicine.Frontiers in veterinary science · 2026Pooled it
- Overweight and Obesity in Dogs and Cats: An Exploration of Animal Welfare and Behaviour Impacts, and Recommendations for Management in Veterinary Primary Care.Animals : an open access journal from MDPI · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is characterized by chronic systemic inflammation accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. A chronic low-grade pro-inflammatory state known as "inflammaging" accelerates age-related diseases such as obesity, diabetes, vascular diseases, and certain types of cancer. Senescent cells drive age-related tissue dysfunction partially by inducing a chronic senescence-associated secretory phenotype (SASP) associated with various diseases. Obesity and insulin resistance change with advancing age and are linked to low-grade chronic inflammation, leading to age-related diseases. Obesity results in significant changes in the adipokine profile, such as reduced levels of anti-inflammatory adipokines, e.g., adiponectin. Cats are more prone to obesity than dogs owing to the unique characteristics of their glucose and lipid metabolism. Severely obese cats show excessive visceral fat accumulation, significantly increased triglyceride, free fatty acids, and TNF-α plasma concentrations as pro-inflammatory markers, and a significant decrease in adiponectin. Aged obese cats with excessive visceral fat exhibit fatty liver and enlarged adipocytes with macrophage infiltration. A healthy lifestyle is recognized as the most effective way to maintain health and fight aging. Aging is inevitable in animals; however, delaying the onset of age-related disease through adequate interventions at the early stages of SASP induction is possible. Adequate nutrition, moderate exercise, and a good mental state can effectively prevent age-related obesity in cats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.