ReviewCureus2025
Effects of Thyroid Dysfunction on Angiogenesis During Wound Healing and Skin Repair: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Maternal Endocrine and Vascular Perturbations Reprogram the Transcriptomic and Secretory Profile of Perinatal Stem Cells: A Comparative Study of Umbilical Cord-Derived Stem Cell UC-MSCs and Human Milk-Derived Stem Cell MM-MSCs.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormones (THs) play an important role in regulating cellular metabolism and tissue homeostasis, particularly influencing angiogenesis, an essential component of wound healing. This systematic review evaluates the current evidence on how thyroid dysfunction, hypothyroidism and hyperthyroidism, impacts angiogenic processes during cutaneous wound repair. A comprehensive search across PubMed, Web of Science, and Scopus identified 61 candidate studies. After applying inclusion criteria focused on original research evaluating TH status and angiogenesis in skin wound models, 26 high-quality studies were included. Evidence demonstrates that hypothyroidism leads to diminished angiogenic activity, delayed re-epithelialization, and decreased expression of vascular markers such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α). Conversely, hyperthyroid conditions showed enhanced neovascularization, although sometimes with dysregulated or excessive remodeling. Emerging experimental therapies, including thyroxine-impregnated biomaterials, nanofiber delivery systems, and stem cell-derived exosomes, also revealed promising angiogenic effects when modulated by THs. This review demonstrates the importance of thyroid status in wound care and highlights therapeutic opportunities for endocrine-modulated vascular repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.