ReviewCureus2025
Impact of Tranexamic Acid on Traumatic Hemorrhage Outcomes in Emergency Medicine: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [Efficacy and safety of emergency administration of tranexamic acid in elderly patients with intertrochanteric femoral fractures].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemorrhage is the predominant cause of death among trauma patients. Therefore, pharmacological treatments such as tranexamic acid (TXA) have been explored to supplement the conventional measures of controlling bleeding in this population. TXA has been found beneficial among patients undergoing elective surgery. However, its use to mitigate bleeding among trauma patients in different settings remains controversial. Therefore, we carried out this study to examine the efficacy of prehospital and in-hospital TXA among trauma patients in military and civilian settings. PubMed, MEDLINE, Cochrane Center Register of Controlled Trials (CENTRAL), ProQuest, and Google Scholar databases were searched for observational and randomized controlled trials (RCTs) related to our topic. Two authors independently abstracted the data required for review and analysis and recorded them in a standardized table. When possible, meta-analysis was performed using the Review Manager software (RevMan 5.4.1, The Cochrane Collaboration, London, UK). Of the 5383 articles obtained from the database search, only 22 met our inclusion criteria. Data pooled from five of these studies showed that prehospital TXA had a non-significant decrease in mortality (OR: 0.91; 95% CI: 0.71 - 1.17; p = 0.45; I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.