ArticleCureus2025
Small Cell Neuroendocrine Carcinoma of the Gallbladder: Natural History and Therapeutic Challenges.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small cell neuroendocrine carcinoma (SNEC) of the gallbladder is an extremely rare and aggressive primary gallbladder malignancy with poor prognosis. A 65-year-old woman presented with constipation followed by jaundice and right upper quadrant pain one month later. Imaging revealed a porta hepatis mass with hepatic and duodenal involvement. Fine needle aspiration confirmed metastatic small cell carcinoma positive for synaptophysin, chromogranin, and CDX2 with Ki-67 >70%. Despite planned platinum-etoposide chemotherapy, rapid disease progression with inferior vena cava invasion precluded treatment. The patient died 13 weeks after symptom onset. This case demonstrates the aggressive natural history of gallbladder SNEC. Early tissue diagnosis and prompt platinum-etoposide chemotherapy initiation while performance status permits remain critical for meaningful survival benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.