Evidence map›Paper›PMID 41158909›Full record

ArticleCureus2025

Impact of Hearing Loss on Memory Loss in Patients With Self-Reported Olfactory Dysfunction.

Mitali Sakharkar, Asritha Sure, Mingqian Tan, Marianella Paz-Lansberg, Jessica Levi

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In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mitali SakharkarDepartment of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, USA.
Asritha SureDepartment of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, USA.
Mingqian TanDepartment of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, USA.
Marianella Paz-LansbergDepartment of Otolaryngology and Rhinology, Boston Medical Center, Boston, USA.
Jessica LeviDepartment of Otolaryngology and Pediatric Otolaryngology, Boston Medical Center, Boston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction The association between hearing loss and dementia, and olfactory dysfunction (OD) and dementia, respectively, is well-elucidated. Several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, impact the olfactory system early in their progression. Despite these established correlations, the independent effect of hearing loss on memory in patients with self-reported olfactory dysfunction is poorly elucidated, which this study aims to investigate, especially in light of the prevalence of anosmia post-COVID-19. Methods A total of 591 records of adult patients with self-reported olfactory dysfunction without a history of traumatic brain injury (TBI) from 2015 to 2020 from a single academic institution were analyzed. Patients were stratified based on demographic, memory loss (including mild cognitive impairment (MCI)), and clinical factors. Univariate and multicollinearity analyses assessed for correlations, with significant covariates utilized in a logistic regression model. Results In univariate analyses, hearing impairment (p<0.001), history of stroke (p<0.001), coronary artery disease (CAD) (p<0.001), hypertension (HTN) (p<0.001), and obstructive sleep apnea (OSA) (p=0.020) were significant. Primary language spoken, smoking history, myocardial infarction (MI), and diabetes mellitus (DM) were not significant. In logistic regression, hearing impairment was significantly associated with memory loss (p<0.001). Other significant covariates included stroke (p=0.004), CAD (p=0.022), and HTN (p<0.001). Conclusions Our results show that hearing impairment is significantly associated with memory loss, specifically in patients with self-reported olfactory dysfunction. This highlights the increased risk of memory loss in this population, underscoring the need for further research into screening and pathophysiology of memory loss in hard-of-hearing patients with olfactory dysfunction post-COVID-19.

Indexed as

cognitive impairmentdementiahearing lossmemory lossolfactory dysfunction

Identifiers

PMID41158909
PMCPMC12558615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.