Evidence map›Paper›PMID 41158867›Full record

ArticleiScience2025

Anthrax ET activates Rac1 and RTK signaling to induce F-actin reorganization and endothelial permeability.

Prashant Jain, Annabel Guichard, Mahtab Moayeri, Saluja Kaduwal, Margot Mel de Fontenay, Ian Rousseau, Stephen H Leppla, Ethan Bier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prashant JainSection of Cell and Developmental Biology, UCSD, La Jolla, CA 92093-0335, USA.
Annabel GuichardSection of Cell and Developmental Biology, UCSD, La Jolla, CA 92093-0335, USA.
Mahtab MoayeriMicrobial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Disease, NIH, Bethesda, MD 20892-3202, USA.
Saluja KaduwalSection of Cell and Developmental Biology, UCSD, La Jolla, CA 92093-0335, USA.
Margot Mel de FontenaySection of Cell and Developmental Biology, UCSD, La Jolla, CA 92093-0335, USA.
Ian RousseauSection of Cell and Developmental Biology, UCSD, La Jolla, CA 92093-0335, USA.
Stephen H LepplaMicrobial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Disease, NIH, Bethesda, MD 20892-3202, USA.
Ethan BierSection of Cell and Developmental Biology, UCSD, La Jolla, CA 92093-0335, USA.

Funding

The mutagenic chain reaction: a method for autocatalyic gene disseminationR01GM117321 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BIER, ETHAN · 2016 to 2024
$2.5M
Development of next-generation gene drive technologies for Anopheles population engineeringR01AI162911 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BIER, ETHAN · 2021 to 2025
$2.3M
Analysis of homolog-based CRISPR editing in somatic cellsR01GM144608 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BIER, ETHAN · 2022 to 2025
$1.3M
Analysis of active genetic elements in germline and somatic cell lineagesR35GM158085 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ETHAN BIER · 2025 to 2026
$1.0M
NIAID NIH HHS R01 AI162911NIGMS NIH HHS R01 GM117321NIGMS NIH HHS R01 GM144608NIGMS NIH HHS R35 GM158085
6 · The paper itself

Abstract

Endothelial permeability induced by the potent adenylate cyclase edema toxin (ET) is central to bacterial dissemination and lethal vascular collapse during infections caused by

Indexed as

BiochemistryBiological sciencesCell biologyNatural sciences

Identifiers

PMID41158867
PMCPMC12555787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.