SynthesisFrontiers in pediatrics2025
The role of cytochrome P450 genetic variants in pesticide metabolism and the risk of child neurodevelopment: a systematic review.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Mechanistic Evaluation of Chlorfenapyr-Induced Hepatotoxicity and the Mitigating Actions of Resveratrol-Loaded Chitosan Nanoparticles.Journal of applied toxicology : JAT · 2026Article
- Oxidative Stress, Environmental Pollutants, Aging, and Epigenetic Regulation: Mechanistic Insights and Biomarker Advances.Antioxidants (Basel, Switzerland) · 2026Review
- The microbial strategies for the management of chemical pesticides: A comprehensive review.Current research in microbial sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Child neurodevelopment is influenced by genetic variants in cytochrome P450 (CYP450) enzymes, which affect detoxification and oxidative stress pathways. These variations modulate susceptibility to environmental toxins, influencing brain development through gene-environment interactions that impact neurogenesis, synaptogenesis, and inflammation, potentially contributing to neurodevelopmental disorders. This review has a major question to answer: how do CYP450 gene polymorphisms modulate pesticide metabolism and contribute to neurodevelopmental risks in children? Method: This study has been conducted according to PRISMA and includes studies conducted from 2005 to 2025. It has been registered to PROSPERO with the number PROSPERO 2024 CRD42024617478. The databases used for the search included PubMed/MEDLINE, Embase, Scopus, and African Journals Online (AJOL). Additional sources, such as OpenGrey, institutional repositories, and conference proceedings, were also searched using targeted search strategies and robust inclusion criteria, which were employed in study selection and final review to analyze gene-environment interactions and developmental outcomes. Results: A total of 758 studies were identified through database searches and manual reference checks. After eliminating studies due to various factors, 176 eligible studies were selected by reviewing the titles and abstracts. Finally, a total of nine articles were included in this systematic review. The review identified CYP3A4 as the most polymorphic gene, followed by CYP2C9, CYP2B6, and CYP1A2-all involved in pesticide metabolism, particularly organophosphates such as chlorpyrifos. Evidence from nine studies suggests that CYP450 polymorphisms influence pesticide detoxification capacity, increasing neurodevelopmental risks in exposed children. These findings highlight the importance of genetic risk assessment in public health strategies targeting pesticide-exposed populations. Conclusion: This review highlights the role of CYP450 gene polymorphisms in increasing susceptibility to pesticide-related neurotoxicity, especially in children and agricultural workers, emphasizing the need for genetically based risk assessment in public health strategies. Systematic Review Registration: PROSPERO CRD42024617478.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.