ArticleInfection and drug resistance2025
tNGS Reveals Predominant Mixed Viral Infections in a Multicenter Retrospective Study.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Associations of Mycoplasma pneumoniae load, co-infections, and macrolide resistance with clinical-laboratory profiles in hospitalized pediatric pneumonia: a targeted next-generation sequencing study of bronchoalveolar lavage fluid.Annals of clinical microbiology and antimicrobials · 2026Article
- Review of the Microbial Spectrum of Mixed Respiratory Fungal Infections.Journal of epidemiology and global health · 2026Review
- Application value of next generation sequencing technology for pathogen detection in patients with pulmonary infection and lung cancer.American journal of cancer research · 2026Article
- Clinical Impact of Polymicrobial Interactions in Human-Metapneumovirus-Infected Children: A Targeted Next-Generation Sequencing Based Retrospective Study.Infection and drug resistance · 2026Article
- Application Research of Targeted Next-Generation Sequencing Technology Based on Bronchoalveolar Lavage Fluid in the Diagnosis of Pulmonary Tuberculosis and Drug-Resistance Detection.Infection and drug resistance · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Purpose: Viral respiratory infections can damage epithelial cells and suppress host immunity, thereby predisposing patients to secondary bacterial or fungal infections. Accurate and timely identification of co-pathogens remains a clinical challenge. We aimed to examine whether tNGS can more comprehensively identify viral and mixed infections in comparison to conventional methods. Patients and Methods: We retrospectively analyzed 834 patients tested using targeted next-generation sequencing (tNGS) and 2263 patients tested using conventional methods across multiple centers. Pathogen profiles-including viral, bacterial, fungal, and atypical microorganisms-were compared between the groups. Results: Compared with conventional diagnostic methods, tNGS detected significantly higher proportions of viral co-infections, including fungal pathogens (eg, Conclusion: Targeted next-generation sequencing identified a higher prevalence and broader spectrum of viral co-infections and secondary bacterial/fungal infections compared with conventional methods. These findings highlight the complexity of respiratory infections in the post-COVID-19 era and support the potential of tNGS as a comprehensive diagnostic approach in clinical practice.
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