Risk Factors for Histologic Chorioamnionitis Among Women with Prenatal Fever During Preterm Delivery: A Retrospective Cohort Study.

Nan Lin, Yiru Shi, Yuanqing Xia, Yunfan Yang, Renyi Hua

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Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Nan Lin *Department of Obstetrics, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.

Yiru Shi *Department of Obstetrics, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.

Yuanqing XiaDepartment of Obstetrics, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.

Yunfan YangDepartment of Obstetrics, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.

Renyi HuaDepartment of Obstetrics, the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: Histologic chorioamnionitis (HCA) complicates preterm birth and adversely affects neonatal and maternal outcomes; however, early recognition remains challenging. Here, we aimed to identify risk factors for HCA and assess its impact on pregnancy outcomes in preterm deliveries with prenatal fever. Design: Retrospective cohort analysis. Setting: Tertiary obstetrics and Gynecology Hospital in Shanghai, China. Participants: A total of 220 women who delivered preterm (gestational age <37 weeks) with prenatal fever between January 2018 and December 2020 were ultimately included in the study. This included an HCA group (101 cases) and control group (119 cases). Main Outcome Measures: HCA diagnosis by placental pathology; neonatal outcomes. Results: The incidence of congenital infection (27.66 vs 15.38%, P=0.029) and neonatal sepsis (8.89 vs 0.90%, P=0.017) was significantly greater in the HCA group than in the control group. Fever interval and PROM between 24 to 48 h (aOR=3.603, 95% CI 1.027~12.644) and >48 h (aOR=6.201, 95% CI 1.729~22.238) were associated with HCA. A maternal WBC count ≥11×10 Conclusion: HCA significantly increases the risks of neonatal sepsis and congenital infection in preterm infants. A prolonged PPROM-fever interval (> 24 h) and a maternal WBC ≥11×10

Indexed as

histologic chorioamnionitisprenatal feverpreterm birthpreterm premature rupture of membranes

Identifiers

PMID41158663

DOI10.2147/IJWH.S542606

PMCPMC12558084

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