SynthesisFrontiers in nutrition2025
Assessment of the influence of vitamin D in patients with sepsis: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Vitamin D Status and Sepsis Outcomes: A PRISMA-Compliant Umbrella Review and Meta-Analysis.Nutrients · 2026Pooled it
- Admission 25-Hydroxyvitamin D Deficiency Is Associated with Poor Outcomes in ICU Patients with Sepsis-Associated Encephalopathy (SAE).Journal of clinical medicine · 2026Article
- Association of vitamin D with sepsis incidence and mortality: a large population-based prospective cohort study.Critical care (London, England) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This systematic review and meta-analysis seeks to extensively estimate the interrelation between vitamin D (VD) and clinical results among both pediatric and adult sepsis patients. Methods: A search was implemented through four databases (PubMed, Embase, Cochrane Library, and Web of Science) up to February 2025. Meta-analysis was implemented utilizing Stata 15 and Meta-Disc software. Results: Thirty-nine studies were included, encompassing 1,208 pediatric and neonatal sepsis patients, and 60,566 adult sepsis patients. The results showed that the average VD level in neonates with sepsis was 12.99 (95% CI: 8.11, 17.87), and the average VD level in children was 24.84 (95% CI: 21.34, 28.33). Their VD levels were considerably lower relative to healthy individuals or those without sepsis, with statistical distinction ( Conclusion: Vitamin D status in both pediatric and adult sepsis individuals was predominantly in a deficient state, and the prevalence of VD deficiency and insufficiency is relatively high. VD deficiency was considerably linked to elevated mortality among pediatric sepsis individuals and also the incidence and mortality of adult sepsis individuals. VD may serve as a valuable biomarker to forecast mortality among adult sepsis individuals. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420250651346, CRD420250651346.
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