ArticleFrontiers in nutrition2025
C-reactive protein-albumin-lymphocyte (CALLY) index predicts overall survival in elderly Japanese patients with dysphagia: a retrospective cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Day-7 caloric intake as an early dynamic prognostic marker for subsequent mortality in older patients with dysphagia: a landmark cohort analysis.Frontiers in nutrition · 2026Article
- Albumin-related nutritional indices and all-cause and cause-specific mortality in older adults with severe dysphagia receiving artificial feeding.Frontiers in nutrition · 2025Article
- Association of the lymphocyte-to-C-reactive protein ratio with long-term mortality in hospitalized older adults with severe dysphagia.Frontiers in nutrition · 2025Article
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5 authors.
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Abstract
Background: The C-reactive protein-albumin-lymphocyte (CALLY) index serves as an established prognostic biomarker across multiple severe disease cohorts. Nevertheless, limited research has examined its relationship with overall survival among elderly Japanese individuals experiencing dysphagia. Objective: To evaluate the prognostic utility of the CALLY index for overall survival in a cohort of elderly Japanese patients with dysphagia. Methods: We conducted a retrospective single-center cohort study of 248 patients diagnosed with dysphagia between January 2014 and January 2017. The primary outcome was overall survival. The CALLY index was analyzed both continuously (natural log transformation) and by quartiles. Multivariable Cox proportional hazards models adjusted for relevant demographic, clinical, and nutritional covariates (including age, sex, comorbidities, hemoglobin, feeding modality, and daily caloric intake) were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Restricted cubic spline models assessed dose-response relationships. Kaplan-Meier analysis estimated median survival by CALLY quartile; subgroup analyses examined effect modification. Results: After natural log transformation, the CALLY index was independently associated with improved survival (HR = 0.85, 95%CI: 0.76-0.95, Conclusion: In this cohort of elderly Japanese patients with dysphagia, a higher CALLY index was associated with longer overall survival. These findings support the potential prognostic utility of the CALLY index in this population; prospective and multicentre validation is warranted.
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