SynthesisFrontiers in nutrition2025
Impact of sarcopenia and frailty on outcomes of patients with sepsis or septic shock: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- [Journal club].Zeitschrift fur Gerontologie und Geriatrie · 2026Article
- Sepsis in Frail Older Adults: Tailored Antimicrobial Stewardship and Individualized Care Approach.Antibiotics (Basel, Switzerland) · 2026Review
- Triglyceride-Glucose Index Modifies Mortality Risk Across Body Mass Index Strata in Critically Ill Patients: A Retrospective Cohort Analysis of the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- Sarcopenia and sepsis fuel a self-perpetuating cycle of immunometabolism decline.Frontiers in immunology · 2026Review
- Sarcopenia Index trajectories predict long-term mortality in super-elderly patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sarcopenia and frailty are emerging risk factors that may modify outcomes in patients with sepsis or septic shock. This review aims to assess the association of sarcopenia and frailty with mortality, length of stay in the hospital and intensive care unit (ICU), and duration of mechanical ventilation in adults with sepsis. Methods: The PubMed, EMBASE, Scopus, CINAHL, Web of Science, and CENTRAL databases were searched from inception to May 31, 2025, for observational studies reporting outcomes stratified by sarcopenia and/or frailty in sepsis. Random-effects meta-analyses (Der Simonian-Laird) were done, and the data were presented as pooled odds ratios (OR) for mortality and weighted mean differences (WMD) for continuous outcomes. Cochran's Q and Results: Thirty studies ( Conclusion: Sarcopenia independently predicts worse mortality and prolonged hospitalization in sepsis, underscoring the need for early muscle-preserving interventions. Frailty prolongs ICU stay and may inform shared-decision discussions, although its impact on mortality is less consistent. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251058423, CRD420251058423.
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Registered trials
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