SynthesisFrontiers in endocrinology2025
The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Molecular Mechanisms Associated with Metabolic Dysfunction: Contributions of Nutritional Genomics.Metabolites · 2026Review
- Adipokine profiles and genetic variants of leptin receptor, adiponectin, and ghrelin pathways in obesity: prospective 12-month outcomes after bariatric interventions.Frontiers in endocrinology · 2026Observational
- Leptin-Independent Association Between SNVs in the Leptin Gene and HDL-C and Apo-AI in Children.International journal of molecular sciences · 2025Article
- Exosomes in pancreatic islet biology and diabetes: Mechanisms, Biomarkers, and potential therapeutic perspectives.Journal of molecular histology · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Background: The associations between the rs7799039 variant in the promoter region of the leptin gene ( Methods: Eligible studies were identified through a search of PubMed, Google Scholar, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases. A random-effects model was employed, and the standardized mean difference (SMD) with 95% confidence interval (95% CI) was calculated to assess the differences in leptin levels and glucose-lipid metabolism markers between subjects with different genotypes of the rs7799039, rs1137100, rs1137101, or rs1805094 variants. Heterogeneity among studies was evaluated using Cochran's Q-test, based on the χ² statistic. Publication bias was assessed using Begg's test. Results: A total of 33 studies (10,471 subjects) for the rs7799039 variant, 12 studies (6,595 subjects) for the rs1137100 variant, 48 studies (18,890 subjects) for the rs1137101 variant, and 20 studies (5,051 subjects) for the rs1805094 variant were included in the pooled analyses. A significant association was found for A-allele carriers of Conclusions: The meta-analysis suggests that the A allele of Systematic review registration: , identifier CRD42025373543.
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