ReviewEndocrine oncology (Bristol, England)2025
Impact of single nucleotide variants in estrogen genes on ovarian cancer risk: a systematic review and meta-analysis.
Review in Endocrine oncology (Bristol, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Modifiable Lifestyle and Environmental Determinants of Ovarian Cancer Risk: Implications for Primary Prevention.Healthcare (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian cancer research increasingly emphasizes the role of genetic factors, particularly estrogen, a key hormone also implicated in breast cancer. Hypotheses such as incessant ovulation and hormonal stimulation of ovarian epithelial cells support a hormonal etiology for ovarian cancer. This systematic review and meta-analysis evaluated the association between estrogen-related gene polymorphisms and ovarian cancer susceptibility. A comprehensive search was conducted in EMBASE, LILACS, PubMed, Scopus, Web of Science, and Google Scholar. Study selection, data extraction, and risk of bias assessment were performed independently by five reviewers. We included observational studies in humans, with no restrictions on language or publication date that investigated associations between estrogen-related gene polymorphisms and ovarian cancer occurrence or susceptibility. Exclusion criteria included studies not addressing the research question, those involving non-human subjects, secondary analyses, and genes unrelated to estrogen. Thirty studies met inclusion criteria. Meta-analysis showed that the A allele of rs4680 in the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.