ArticleERJ open research2025
Lung MRI scoring reveals persistence of emphysema-like changes in lungs of infants born preterm at (pre)school age.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Follow-up of neonatal chronic respiratory disease: an update based on the current evidence.European journal of pediatrics · 2026Review
- The characteristics of pulmonary fibrosis in a neonatal rat model of chronic hyperoxia lung injury.Translational pediatrics · 2025Article
- Keeping it simple: lung imaging of alveolar simplification in preterm-birth children.ERJ open research · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic lung disease, Methods: (Pre)school-aged children after premature birth with and without BPD underwent 3T MRI without sedation at a median age of 5.8 years (4.3-8.7 years, n=27). Comparative analyses used imaging at near-term age in 88 preterm infants with a subgroup of 16 serial measurements. Standardised image analysis (consensus panel scoring, 5-point Likert scale) of coronal/axial/sagittal T2-weighted single-shot fast-spin-echo sequences obtained scores for the variables "emphysema", "interstitial enhancement", "airway accentuation" and "ventilation inhomogeneity", complemented by transverse (T2) and longitudinal (T1) relaxation-time mapping (n=26), lung volume measurements and follow-up parental questionnaires. Results: MRI scoring revealed persisting emphysema-like changes in children with moderate/severe BPD (p=0.031 Interpretation: Persisting structural changes in the BPD lung are dominated by underlying immaturity and demonstrate an emphysema-like phenotype, potentially fitting the concept of dysanapsis. Lung MRI can inform treatment and monitoring strategies through the provision of additional information on disease characteristics and severity.
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Registered trials
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