Evidence map›Paper›PMID 41158504›Full record

ArticleERJ open research2025

Prenatal exposure to air pollution affects autophagy, senescence and remodelling proteins in cord blood.

Olga Gorlanova, Heide Oller, Uri Nahum, Noëmi Künstle, Loretta Müller, Andrea Marten, Céline Rüttimann, Danielle Vienneau, Kees de Hoogh, Primo Schär and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Olga GorlanovaUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Heide OllerUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Uri NahumUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Noëmi KünstleUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Loretta MüllerUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Andrea MartenUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0008-3853-1276
Céline RüttimannUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Danielle VienneauSwiss Tropical and Public Health Institute, Allschwil, Switzerland.ORCID https://orcid.org/0000-0002-6309-6439
Kees de HooghSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Primo SchärDepartment of Biomedicine, University of Basel, Basel, Switzerland.
David SchürmannDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-2904-1378
Carla Rebeca Da Silva SenaUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Martin RöösliSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Philipp LatzinUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-5239-1571
Pablo SinuesUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Sven SchulzkeUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.
Ruth SteinbergUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-4108-6085
Jakob UsemannUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-9987-2866
Pawan SharmaDepartment of Pathology and Laboratory Medicine, Center for Inflammation and Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-2904-2306
Urs FreyUniversity Children's Hospital (UKBB), University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-3773-2822

Funding

E3 ubiquitin ligase RNF145 in airway smooth muscle functions and in asthmaR01HL161205 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Pawan Sharma · 2022 to 2026
$2.4M
NHLBI NIH HHS R01 HL161205
6 · The paper itself

Abstract

Background: Air pollution increases inflammation and reactive oxygen species that can induce autophagy, thereby leading to airway inflammation and remodelling. However, it is unclear whether prenatal air pollution may impact proteins involved in autophagy. The objectives of the present study were to investigate the associations of prenatal air pollution with proteins indicative of autophagy, senescence and remodelling in infants. Methods: We included 387 healthy term newborns from the BILD cohort study and measured 11 proteins: interleukin (IL)-1β, IL-8, matrix metallopeptidase (MMP)-3, MMP-9, platelet-derived growth factor (PDGF)-AA, transforming growth factor-β (TGF-β), sirtuin-1, p62, LC3B, tumour necrosis factor-α (TNF-α), and Beclin-1 in cord blood serum and plasma. We assessed the association of whole pregnancy residential exposure to nitrogen dioxide (NO Results: Our results indicate that NO Conclusions: Our findings in healthy term newborns showed that prenatal air pollution exposure is associated with alterations in levels of autophagy-related proteins. For the first time, we identified four distinct clusters of newborns, suggesting that there are different air pollution response patterns in a healthy population.

Identifiers

PMID41158504
PMCPMC12557426

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.