Evidence map›Paper›PMID 41158446›Full record

ArticleFrontiers in medicine2025

Dermoscopy for monitoring therapeutic response to hybrid cooperative complexes of hyaluronic acid in women with vulvar lichen sclerosus and atrophy.

Giulio Rizzetto, Edoardo De Simoni, Alessandro Borghi, Elisa Molinelli, Marinella Tedesco, Emilia Migliano, Corrado Tagliati, Monica Corazza, Franco Grimolizzi, Gilberto Bellia and 3 more

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giulio RizzettoDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
Edoardo De SimoniDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
Alessandro BorghiDepartment of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.
Elisa MolinelliDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
Marinella TedescoDepartment of Plastic and Regenerative Surgery, San Gallicano Dermatological Institute IRCCS, Rome, Italy.
Emilia MiglianoDepartment of Plastic and Regenerative Surgery, San Gallicano Dermatological Institute IRCCS, Rome, Italy.
Corrado TagliatiDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
Monica CorazzaDepartment of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Ferrara, Italy.
Franco GrimolizziIBSA Farmaceutici Italia Srl, Lodi, Italy.
Gilberto BelliaIBSA Farmaceutici Italia Srl, Lodi, Italy.
Camilla BarduagniDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
Annamaria OffidaniDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.
Oriana SimonettiDermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Vulvar Lichen Sclerosus (VLS) is a chronic relapsing inflammatory disease involving the anogenital region, resulting in vulvar atrophy and distressing symptoms. A preliminary prospective observational study was conducted to investigate the efficacy of hybrid cooperative complexes (HCC) of low- and high-molecular weight hyaluronic acid (HA) for the treatment of female patients with vulvar atrophy and lichen sclerosus. Methods: Female patients with coexisting vulvar atrophy and lichen sclerosus ( Results: Both DLQI and FSFI scores improved with HCC treatment, with significant improvements at 1-month, 3-months and 6-months post-treatment vs baseline ( Discussion: These preliminary results add to the growing body of evidence highlighting the promising efficacy of HCC of HA for the treatment of VLS.

Indexed as

hyaluronic acidhybrid cooperative complexesultrasoundvideodermatoscopyvulvar lichen sclerosus

Identifiers

PMID41158446
PMCPMC12558151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.