Evidence map›Paper›PMID 41158398›Full record

ArticleJournal of thoracic disease2025

Perineural invasion as a prognostic factor and the efficacy of upfront surgery for low-risk cT2/T3N0M0 esophageal squamous cell carcinoma patients.

Jicheng Xiong, Simiao Lu, Shuoming Liang, Hainan Chen, Ziwei Wang, Hao Meng, Yan Miao, Qin Xie, Guangyuan Liu, Kangning Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jicheng XiongSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID https://orcid.org/0009-0001-9784-3033
Simiao LuSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Shuoming LiangDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Hainan ChenDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Ziwei WangSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Hao MengSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yan MiaoDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Qin XieDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Guangyuan LiuDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Kangning WangDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Lin PengDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Qiang FangDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Wenguang XiaoDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Qifeng WangDepartment of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Yongtao HanDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Xuefeng LengDepartment of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Provincial Clinical Medical Research Center, Cancer Prevention and Control Center of Sichuan Province, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Controversy remains as to the need for neoadjuvant therapy in the treatment of cT2/T3N0M0 esophageal squamous cell carcinoma (ESCC), with regional (e.g., China Methods: We retrospectively collected the data of 786 cT2/T3N0M0-stage ESCC patients treated between January 2010 and December 2017 to assess the survival outcomes and identify risk factors. Additionally, we performed a survival analysis to explore the prognostic factors in this patient subgroup. Results: The cT2N0-stage and cT3N0-stage ESCC patients had 5-year OS rates of 68.0% and 59.0%, respectively (median OS: 82.7 Conclusions: Upfront surgery results in favorable long-term survival outcomes in cT2/T3N0M0-stage ESCC patients without PNI. These findings show the importance of tailoring therapeutic strategies to distinct ESCC subgroups, particularly based on PNI status and tumor differentiation.

Indexed as

Esophageal squamous cell carcinoma (ESCC)lymphovascular invasion (LVI)overall survival (OS)perineural invasion (PNI)surgery

Identifiers

PMID41158398
PMCPMC12557706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.