ArticleJournal of thoracic disease2025
Diagnostic accuracy of computer-aided detection (CAD)-derived solid component proportion and mean CT attenuation for predicting invasiveness in pulmonary part-solid nodules: a retrospective study.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Prognostic and Mutational Characteristics of Multiple Early-stage Lung Cancers Manifesting as Subsolid Nodules.Current medical imaging · 2026Article
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7 authors.
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Abstract
Background: Accurate preoperative identification of invasiveness in pulmonary part-solid nodules (PSNs) is critical to guide extent of resection and operative timing, yet reliable, automated imaging markers are limited. This study aimed to evaluate the predictive value of volumetric proportion and mean computed tomography (CT) value of solid components for the invasiveness of pulmonary PSNs using computer-aided detection (CAD). Methods: This retrospective study included 313 patients with 324 PSNs who underwent thin-section CT (TSCT) before surgery and had postoperative pathologic diagnoses of atypical adenomatous hyperplasia (AAH), adenocarcinoma Results: Among 313 patients (324 PSNs; median age 58 years), 4 AAH, 88 AIS, 69 MIA, and 163 IA were identified. The mean CT value of the solid component had an AUC of 0.795 (threshold -144.5 HU), with sensitivity 0.799, and specificity 0.696. Tumor size had an AUC of 0.784 (threshold 1.65 cm, sensitivity 0.595, specificity 0.826), and solid component size had an AUC of 0.759 (threshold 0.95 cm, sensitivity 0.804, specificity 0.509). Analysis of solid component proportion demonstrated AUCs of 0.795 and 0.783 at -300 and -400 HU, respectively, with corresponding optimal thresholds of 16.2% (sensitivity 0.706, specificity 0.814) and 31.3% (sensitivity 0.687, specificity 0.807). In the stratified analysis, the mean CT value and solid component proportion showed high AUCs in all tumor size strata. Conclusions: CAD-derived volumetric solid proportion and mean CT attenuation show promise for predicting PSN invasiveness in this single-center retrospective cohort; prospective multicenter validation with standardized protocols is warranted.
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