ArticleJournal of thoracic disease2025
The impact of the toll-like receptor 1 (TLR1) variation rs5743557 on tuberculosis susceptibility in the Thai population.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Tuberculosis (TB) remains a major public health concern in Thailand and worldwide. Genetic factors, including single nucleotide polymorphisms (SNPs), play a part in influencing susceptibility to TB. The aim of this study was to investigate the allele and genotype frequencies of the rs5743557 (G>A) polymorphism and its potential impact on TB susceptibility in the Thai population. Methods: A total of 149 leftover peripheral blood mononuclear cell (PBMC) samples were collected and divided into two groups: patients with TB (TB group, n=92) and patients without TB (non-TB group, n=57). TaqMan real-time polymerase chain reaction (PCR) was performed for genotyping. Logistic regression analysis was performed to assess the association between rs5743557 (G>A) and susceptibility to TB. Results: The analysis revealed that the A allele of the rs5743557 variant was relatively prevalent in the study population. Although a trend indicated that individuals carrying the A allele may have a reduced probability of developing TB, the association did not reach statistical significance. Conclusions: Our findings reveal a trend of reduced TB susceptibility in rs5743557 allele A, although it did not reach statistical significance. There is clinical relevance, marking a promising starting point for further research within the Thai population. In addition, this perspective opens avenues for future research efforts in the field. Clinical Trial Registration: https://www.thaiclinicaltrials.org/ (TCTR20220506002, registered on May 6, 2022).
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