ArticleJournal of thoracic disease2025
A study on the influencing factors of early clinical stability in patients with acute exacerbation of chronic obstructive pulmonary disease complicated by pneumonia.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disorder characterized by persistent airflow obstruction, posing a significant threat to public health. During the acute exacerbation stage, especially when complicated by pneumonia, patients' conditions may deteriorate rapidly, leading to increased hospitalization rates, medical costs, and mortality risk. Early clinical stability is crucial for evaluating the severity and prognosis of COPD patients in such circumstances. The aim of this study was to explore the related factors affecting the early clinical stability of patients with acute exacerbation of COPD accompanied by pneumonia and to provide a basis for early identification of high-risk patients and formulation of personalized treatment plans. Methods: This retrospective study included 713 patients with acute exacerbation of COPD complicated by pneumonia admitted to the Clinical Medical College & Affiliated Hospital of Chengdu University from December 2017 to December 2018. Patients were divided into stable and unstable groups based on clinical stability indicators within 72 hours after treatment. Data on demographic characteristics, clinical manifestations, laboratory test indicators, and clinical assessment scores were collected. Statistical analysis was performed using SPSS 26.0 and R software, including independent sample Results: Significant differences were observed between the stable and unstable groups in age, comorbidities, vital signs, laboratory indicators, and clinical assessment scores. Multivariate logistic regression analysis revealed that white blood cell count (WBC), hemoglobin (Hb), sleep impact score, hydrogen carbonate ion (HCO Conclusions: This study identified several independent factors affecting the early clinical stability of patients with acute exacerbation of COPD and pneumonia. These findings provide valuable insights for clinicians to identify high-risk patients early and develop personalized treatment plans, potentially improving clinical outcomes and reducing mortality and medical burden.
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