ReviewFrontiers in transplantation2025
Comparative systematic review and meta-analysis of pregnancy outcomes after kidney transplantation.
Review in Frontiers in transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Introduction: Advancements in transplant medicine have increased the incidence of pregnancy among kidney transplant recipients. These pregnancies, however, carry elevated maternal and neonatal risks, warranting comprehensive outcome evaluation. Materials and methods: To compare key maternal and neonatal outcomes in pregnancies following kidney transplantation with those in healthy pregnancies. A systematic search of MEDLINE, Embase, and PubMed was conducted up until December 2024. Comparative prospective and retrospective observational studies reporting maternal or neonatal outcomes in pregnancies among kidney transplant recipients and healthy controls. Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) was used for quality assessment. Random-effects meta-analyses were conducted to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) and heterogeneity ( Results: Eight studies encompassing 893 pregnancies post-kidney transplantation were included. Relative to healthy pregnancies, kidney-transplant recipients showed markedly higher odds of pre-eclampsia (OR: 10.17, 95% CI: 4.25-24.35; Conclusions: Pregnancies following kidney transplantation are associated with significantly increased maternal and neonatal risks. These findings underscore the need for specialized antenatal care and further large-scale prospective studies to optimize outcomes and inform clinical guidelines.
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