ArticleMedical review (2021)2025
Trophoblast-derived exosomes containing PD-L1 may have protective effects on preeclampsia by regulating Tregs.
Article in Medical review (2021), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Once maternal-fetal immune tolerance is broken, pregnancy complications such as preeclampsia (PE) will occur. Regulatory T cells (Tregs) as unique immunosuppressive cells, play an important role in this whole process. Programmed cell death 1 ligand 1 (PD-L1) is widely expressed in human placental trophoblasts, through binding with programmed cell death protein 1 (PD-1) to maternal-fetal immunomodulation. Exosomes belong to extracellular membrane-bound microvesicles (EMV) that get more and more attention in signaling pathways and disease regulation. The role of Tregs in the development of PE and the role of PD-1/PD-L1 in regulating the function of Tregs have been studied, but the mechanism of trophoblast-derived exosomes containing PD-L1 influences PE by mediating maternal-fetal interface immunity is still unclear. In this article, our specific hypothesis is that trophoblast-derived exosomes containing PD-L1 which may decrease in PE could regulate the proportion and differentiation of Tregs in the decidua. This mechanism of suppression must be further investigated as it may provide valuable clues to novel therapeutic design in the realm of PE research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.