ArticleLung Cancer (Auckland, N.Z.)2025
Successful and On-going Long-Term Disease Control (>24 Months) with Gilteritinib in an
Article in Lung Cancer (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Despite the approval to date of 3 generations of ALK tyrosine kinase inhibitors (TKIs) and the clinical development of a 4 Case Description: Patient is currently an 82-year-old African-American female never-smoker who was diagnosed with stage 4 NSCLC at age 62. Almost 7.5 years after initial diagnosis and after disease progression on multiple chemotherapy regimens, her tumor was found to harbor an Conclusion: This is the first patient case report with >24 months on-going follow-up demonstrating that gilteritinib could be repurposed as a potent and tolerable ALK inhibitor based on previously reported pre-clinical activity and with potential CNS activity. A Phase 2 trial of gilteritnib in alectinib- or lorlatinib-refractory
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