ArticleJournal of hepatocellular carcinoma2025
The Long Non-Coding RNA SNHG16 Negatively Regulates Let-7 and Predicts Recurrence in Hepatocellular Carcinoma.
Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Let-7, a family of microRNA (miRNA) that regulates the timing of cell division, is associated with tumorigenesis and tumor progression. The factors that regulate let-7 and affect the prognosis of hepatocellular carcinoma (HCC) warrant further investigation. Patients and Methods: In this study, we first utilized the data from The Cancer Genome Atlas (TCGA) and employed bioinformatics methods to analyze the expression and function of let-7 in HCC. Subsequently, we retrieved the long non-coding RNAs (lncRNAs) that regulate let-7 from the StarBase database. Finally, through bioinformatics analysis of the TCGA-LIHC data and validation with clinical samples, we explored the relationship between let-7 and its related lncRNAs and clinical indicators such as HCC recurrence and survival. Results: Let-7c was significantly downregulated in HCC, regulating tumor progression via pathways like PI3K-Akt and tumor-related miRNAs. LncRNAs SNHG16 negatively regulated let-7c expression in HCC ( Conclusion: SNHG16 negatively regulates let-7c and serves as a prognostic biomarker for HCC recurrence and survival.
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