Spindle localization of YAP/TAZ maintains even distribution of YAP/TAZ in daughter cells.

Yuxing Huang

Abstract read

In one paragraph

Article in Journal of biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

1 author.

Yuxing HuangDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

YAP and TAZ are downstream effectors of the Hippo signaling pathway, known to shuttle between the cytoplasm and nucleus, where they primarily function as transcriptional coactivators. Although their nuclear role has been well characterized, the non-transcriptional functions of YAP/TAZ remain poorly understood. In this study, we report that YAP/TAZ localize to the metaphase spindle in a microtubule-dependent manner. Specifically, we demonstrate that YAP interacts with α-tubulin via its WW domain. Notably, while the spindle localization of YAP/TAZ does not affect the mechanics of mitotic cell division, it does influence the distribution of YAP/TAZ protein levels between the resulting daughter cells. These findings reveal a novel, nontranscriptional role for YAP/TAZ during mitosis.

Indexed as

Adaptor Proteins, Signal TransducingIntracellular Signaling Peptides and ProteinsPhosphoproteinsSpindle ApparatusTranscription FactorsCell Cycle ProteinsCell NucleusHeLa CellsHumansMicrotubulesMitosisSignal TransductionTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTubulinYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsIntracellular Signaling Peptides and ProteinsPhosphoproteinsTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsTubulinWWTR1 protein, humanYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID41157900

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.