Evidence map›Paper›PMID 41157889›Full record

ArticleThe FEBS journal2026

Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products.

Nicole G H Leferink, Joshua N Whitehead, Linus O Johannissen, Nigel S Scrutton

Abstract read
In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicole G H LeferinkFuture Biomanufacturing Research Hub (FBRH), Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, UK.
Joshua N WhiteheadFuture Biomanufacturing Research Hub (FBRH), Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, UK.
Linus O JohannissenManchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, UK.
Nigel S ScruttonFuture Biomanufacturing Research Hub (FBRH), Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, The University of Manchester, UK.ORCID 0000-0002-4182-3500

Funding

Engineering and Physical Sciences Research Council EP/S01778X/1
6 · The paper itself

Abstract

1,8-cineole synthase from Streptomyces clavuligerus (bCinS) is the only known bacterial terpene synthase that shows exclusive activity towards the monoterpene substrate geranyl diphosphate (GPP; C

Indexed as

Alkyl and Aryl TransferasesBacterial ProteinsDiterpenesSesquiterpenesStreptomycesCatalytic DomainDiphosphatesEucalyptolIntramolecular LyasesMutagenesis, Site-DirectedPolyisoprenyl PhosphatesSubstrate SpecificityAlkyl and Aryl TransferasesBacterial ProteinsDiphosphatesDiterpenesEucalyptolfarnesyl pyrophosphategeranyl diphosphategeranylgeranyl pyrophosphategeranyl pyrophosphateIntramolecular Lyasespinene cyclase IPolyisoprenyl PhosphatesSesquiterpenesterpene synthasecyclisationmutagenesisprotein engineeringsubstrate scopeterpene synthaseterpenoids

Identifiers

PMID41157889
PMCPMC12958101

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.