Efficient Synthesis of Amides through Thioacids Reactions with In Situ Generated Formamidine.

Chin-Ling Kuo, Yan-Jie Chen, Hsiang-Jou Chen, Ching-Ching Yu, Chien-Fu Liang

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Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Organocatalytic Synthesis of Amides Using Thioacids and Anilines via Electron Donor-Acceptor Photoactivation.The Journal of organic chemistry · 2026
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5 · Who and what money

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5 authors.

Chin-Ling KuoDepartment of Chemistry, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung City 402202, Taiwan.

Yan-Jie ChenDepartment of Chemistry, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung City 402202, Taiwan.

Hsiang-Jou ChenDepartment of Chemistry, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung City 402202, Taiwan.

Ching-Ching YuDepartment of Chemistry, National Tsing Huw University,101 Section 2, Kuang Fu Road, Hsinchu 30013, Taiwan.ORCID 0000-0003-2103-6419

Chien-Fu LiangDepartment of Chemistry, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung City 402202, Taiwan.ORCID 0000-0001-8438-5873

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A formamidine intermediate generated in situ was used as the nitrogen source in a reaction with thioacids to obtain amides. The synthetic protocol described in this paper can be used in the generation of various primary, secondary, and tertiary amides with organic thioacids used as substrates under the optimized conditions. Notably, this protocol uses readily available materials, is nearly solvent-free, supports gram-scale synthesis, and yields structurally diverse amide products with favorable efficiency.

Identifiers

PMID41157888

DOI10.1021/acs.joc.5c01644

PMCPMC12604045

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