Evidence map›Paper›PMID 41157860›Full record

ArticlePsychological medicine2025

Psychological side effects of antipsychotic medication after remission from first-episode psychosis: a HAMLETT ecological momentary assessment study.

Matej Djordjevic, Shiral S Gangadin, Lieuwe de Haan, Hannah E Jongsma, Priscilla P Oomen, Claudia J P Simons, Machteld Marcelis, Mark Nijland, Marieke J H Begemann, Iris E C Sommer and 2 more

Abstract read
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In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matej DjordjevicUniversity of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, Groningen, The Netherlands.ORCID 0000-0001-5836-9976
Shiral S GangadinUniversity of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, Groningen, The Netherlands.
Lieuwe de HaanDepartment of Early Psychosis, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Hannah E JongsmaUniversity of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, Groningen, The Netherlands.
Priscilla P OomenBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Claudia J P SimonsDepartment of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, The Netherlands.
Machteld MarcelisDepartment of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, The Netherlands.
Mark NijlandUniversity of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, Groningen, The Netherlands.
Marieke J H BegemannCenter for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Iris E C SommerCenter for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Martijn J KikkertDepartment of Research, Arkin Mental Health Care, Amsterdam, The Netherlands.
Wim VelingUniversity of Groningen, University Medical Center Groningen, University Center for Psychiatry, Rob Giel Research Center, Groningen, The Netherlands.

Funding

ZonMw #848041003 and #636340001
6 · The paper itself

Abstract

backgroundEvidence on psychological side effects (PSEs) of antipsychotic medication after remission from first-episode psychosis (FEP), and their momentary impact on daily life, is limited. This study examined how Dopamine-2 (D

methodsThis ecological momentary assessment (EMA) study included baseline data from 56 participants in the ongoing Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment (HAMLETT) trial. Momentary mental states indicative of reduced affect intensity, stability, and variability, as well as avolition and mental fatigue, were assessed 10×/day for eight days (N = 3,005 data points). Since these PSEs may result from D

resultsHigher antipsychotic dosages were associated with reduced affect variability (Beta [B] = -1.40 [95% confidence interval [CI]: -2.52; -0.29]) and decreased positive affect stability (B = 0.23 [95% CI: 0.04; 0.42]) and intensity (B = -1.11 [95% CI: -1.97; -0.24]). The latter was also associated with the use of high-affinity D

conclusionsHigher antipsychotic dosage and high-affinity D

Indexed as

AffectAntipsychotic AgentsEcological Momentary AssessmentPsychotic DisordersAdolescentAdultCross-Sectional StudiesDose-Response Relationship, DrugFemaleHumansMaleReceptors, Dopamine D2Young AdultAntipsychotic AgentsReceptors, Dopamine D2antipsychotic medicationD2 affinityearly psychosisecological momentary assessmentexperience sampling methodologyfirst-episode psychosispsychopharm acologyschizophrenia spectrum disorderside effects

Identifiers

PMID41157860
PMCPMC13054896

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.