ArticleAdvanced healthcare materials2026
Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Anion-Specific Mechanisms in Fibrinogen Self-Assembly: Contrasting Effects of Phosphates and Chlorides in Nanofiber Formation.Macromolecular bioscience · 2026Article
- Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering.Advanced healthcare materials · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Hematopoietic stem cells (HSCs) can reconstitute the human blood system. In vivo, HSCs are localized in and regulated by distinct bone marrow (BM) microenvironments, or niches, like the vascular HSC niches near fenestrated sinusoidal blood vessels. These delicate structures, comprising a single-layered endothelium and a discontinuous basement membrane, pose challenges in soft tissue engineering. In this study, the basement membrane in vascular niches is mimicked using nanofibrous fibrinogen scaffolds. A novel clamping system enables handling the scaffold as a membrane and seeding both sides-one with microvascular endothelial cells (HMEC-1) and the other with mesenchymal stem and stroma cells (iMSC#3). Subsequently, HSCs and their progenitors (HSPCs) are introduced from both sides to emulate their niche dynamics (residency, exit, and homing). The study reveals that the fibrinogen scaffolds are highly cytocompatible and show good cell-adhesive properties. In addition, HSPCs are able to migrate through the scaffolds, validating them as fenestrated basement membrane mimetics. This in vitro model offers insights into HSPC behavior in the vascular niche and can serve as a drug testing platform in future studies. Moreover, beyond HSCs, the presented scaffold-based mimetic of the basement membrane offers new opportunities for mimicking and studying vasculature in tissue engineering approaches.
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Registered trials
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