Evidence map›Paper›PMID 41157851›Full record

ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Endothelial βII Spectrin Deletion Exacerbates Inflammation and Impairs Tissue Regeneration in Ischemic-Diabetic Skin Wound Healing.

Ruchi Gupta, Paula O Cooper, Weidong Chai, Pritham Mulagura, Sean M Lee, Georgios Theocharidis, Anton N Sidawy, Brett A Shook, Bao-Ngoc Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Endothelial βII Spectrin Deletion Exacerbates Inflammation and Impairs Tissue Regeneration in Ischemic-Diabetic Skin Wound Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
  3. High-Frequency Ultrasound Evaluation of Cutaneous Surgical Wound Healing: An Outpatient Experience.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruchi GuptaDepartment of Surgery, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.ORCID https://orcid.org/0009-0009-9271-9138
Paula O CooperDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Weidong ChaiDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Pritham MulaguraDepartment of Surgery, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Sean M LeeOffice of Clinical Research, The George Washington University, Washington, DC, USA.
Georgios TheocharidisDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Anton N SidawyDepartment of Surgery, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Brett A ShookDepartment of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Bao-Ngoc NguyenDepartment of Surgery, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.

Funding

The role of Poly-ADP-Ribose Polymerase in angiogenesis of ischemic-diabetic woundsK08HL129072 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI NGUYEN, BAO-NGOC · 2018 to 2022
$747k
George Washington University Department of Surgery Fund S0100D010710-01George Washington University Department of Surgery Fund S0100D032420-01Ludwig Family Foundation GrantNHLBI NIH HHS K08 HL129072NIH HHS 5K08HL129072-04
6 · The paper itself

Abstract

Impaired lower extremity wound healing due to diabetes presents a significant societal burden, as 25% of diabetic wounds lead to major amputations. While TGF-β has been extensively studied in diabetic wound healing, the role of βII spectrin (SPTBN1), a known adapter of SMAD3 in the canonical TGF-β signalling pathway, remains unexplored. Single-cell RNA sequencing analysis revealed an increase in SPTBN1 expression in endothelial cells from non-diabetic skin to diabetic skin and ulcers. We found that silencing SPTBN1 in human umbilical vein endothelial cells (HUVECs) suppressed endothelial sprouting and tube formation. Based on these findings, we hypothesised that SPTBN1 regulates diabetic wound healing by modulating angiogenesis. To test this, we created Sptbn1 endothelial-specific conditional knockout (Sptbn1

Indexed as

Diabetes Mellitus, ExperimentalInflammationIschemiaRegenerationSkinSpectrinWound HealingAnimalsDisease Models, AnimalHumansHuman Umbilical Vein Endothelial CellsMiceMice, KnockoutNeovascularization, PhysiologicTransforming Growth Factor betaSpectrinTransforming Growth Factor betaangiogenesisendothelial cellsinflammationischemic‐diabetic wound healingmyeloid cellsSPTBN1TGFβ‐SMAD signallingβII spectrin

Identifiers

PMID41157851
PMCPMC12569399

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.