Evidence map›Paper›PMID 41157635›Full record

ArticleViruses2025

Transcontinental Spread of HPAI H5N1 from South America to Antarctica via Avian Vectors.

Ruifeng Xu, Minhao Gao, Nailou Zhang, Zhenhua Wei, Zheng Wang, Lei Zhang, Yang Liu, Zhenhua Zheng, Liulin Chen, Haitao Ding and 1 more

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruifeng XuWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.ORCID 0009-0003-7240-6464
Minhao GaoPolar Research Institute of China, Shanghai 200136, China.
Nailou ZhangWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Zhenhua WeiPolar Research Institute of China, Shanghai 200136, China.
Zheng WangPolar Research Institute of China, Shanghai 200136, China.
Lei ZhangWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Yang LiuWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Zhenhua ZhengWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.ORCID 0000-0002-4117-9364
Liulin ChenPolar Research Institute of China, Shanghai 200136, China.
Haitao DingPolar Research Institute of China, Shanghai 200136, China.
Wei WangWuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.ORCID 0000-0002-8696-9773

Funding

the National Key Research and Development Program of China 2024YFC2813605,2023YFC2605504
6 · The paper itself

Abstract

During China's 41st Antarctic research expedition, samples were collected from wildlife on the Fildes Peninsula, South Shetland Islands, Antarctica. Real-time RT-PCR screening confirmed H5N1 positivity, representing the first identification of the virus in brown skuas on the Fildes Peninsula. Whole-genome sequences obtained from positive samples via next-generation sequencing were subjected to phylogenetic and phylogeographic analyses. The results revealed that these Antarctic strains are most closely related to H5N1 viruses circulating in South America, particularly from Peru and Chile, suggesting a likely introduction via avian migration routes. Furthermore, a unique 17-amino-acid deletion was identified in the stalk region of the neuraminidase (NA) gene, which is uncommon among globally sampled clade 2.3.4.4b variants. This study confirms the arrival of HPAI H5N1 in the Antarctic continent and underscores the necessity for enhanced surveillance to understand the viral ecology and potential risks within this unique ecosystem.

Indexed as

Influenza A Virus, H5N1 SubtypeInfluenza in BirdsAnimalsAnimals, WildAntarctic RegionsBirdsGenome, ViralNeuraminidasePhylogenyPhylogeographySouth AmericaNeuraminidaseAntarcticaAvianH5N1next-generation sequencing

Identifiers

PMID41157635
PMCPMC12567752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.