Evidence map›Paper›PMID 41157617›Full record

ArticleViruses2025

Sindbis Virus-Host Interactions in Human Neuroblastoma Cells: Implications for Viral Pathogenesis and Replication.

Kornélia Bodó, Zoltán Kopasz, Viktória Nyári, Krisztina Leiner, Péter Engelmann, Brigitta Zana, Roland Hetényi, Dániel Hanna, Krisztián Bányai, Mónika Madai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kornélia BodóNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0001-9429-4377
Zoltán KopaszNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.ORCID 0009-0006-1176-5529
Viktória NyáriNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.
Krisztina LeinerNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.
Péter EngelmannDepartment of Immunology and Biotechnology, Medical School, Clinical Center, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0002-9284-4985
Brigitta ZanaNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.
Roland HetényiNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0003-4390-7924
Dániel HannaNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.ORCID 0009-0001-7093-6491
Krisztián BányaiDepartment of Medical Biology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Mónika MadaiNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.
Gréta VargaNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.
Anett KuczmogNational Laboratory of Virology, Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary.

Funding

National Research, Development and Innovation Office of Hungary 2023-1.1.2-GYORSITOSAV-2024-00020National Research, Development and Innovation Office of Hungary TKP2021-NVA07Research Foundation of the University of Pécs 020_2024_PTE_RK/36Research Foundation of the University of Pécs 020_2024_PTE_RK/6Research Foundation of the University of Pécs 020_2024_PTE_RK/7
6 · The paper itself

Abstract

Sindbis virus (SINV) is a mosquito-borne alphavirus capable of causing neurological and immunological symptoms in humans, yet its effects on neural/immune systems remain insufficiently characterized. This study aimed to examine SINV replication, UV-C light inactivation, apoptosis induction, and immune gene modulation in human SH-SY5Y neuroblastoma cells. Following viral adaptation and infectious dose determination, SINV replication and inactivation were assessed using RT-qPCR and dsRNA immunofluorescence. Apoptotic markers (caspase-3, Bax, Bcl-2) were analyzed by immunofluorescence and immune genes expression kinetics (

Indexed as

Host Microbial InteractionsHost-Pathogen InteractionsNeuroblastomaSindbis VirusVirus ReplicationApoptosisCell Line, TumorHumansRNA, ViralUltraviolet RaysRNA, Viralapoptosisimmune modulationSINVUV-C inactivationviral replication

Identifiers

PMID41157617
PMCPMC12567755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.