Evidence map›Paper›PMID 41157601›Full record

ArticleViruses2025

Rift Valley Fever Virus Transmission During an Unreported Outbreak Among People and Livestock in South-Central Tanzania.

Robert D Sumaye, Ana Pérola D Brandão, Frank Chilanga, Goodluk Paul, Grace W Mwangoka, Woutrina A Smith, Abel B Ekiri, Christopher Kilonzo, Solomon Mwakasungula, George Makingi and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Robert D SumayeIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.ORCID 0000-0001-9734-3226
Ana Pérola D BrandãoOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Frank ChilangaOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Goodluk PaulDepartment of Veterinay Medicine and Public Health, Sokoine University of Agriculture, Morogoro P.O. Box 30 007, Tanzania.
Grace W MwangokaIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.ORCID 0009-0008-7466-7998
Woutrina A SmithOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Abel B EkiriDepartment of Veterinay Medicine and Public Health, Sokoine University of Agriculture, Morogoro P.O. Box 30 007, Tanzania.ORCID 0000-0001-9758-808X
Christopher KilonzoOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Solomon MwakasungulaIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.ORCID 0000-0002-3458-6789
George MakingiDepartment of Veterinay Medicine and Public Health, Sokoine University of Agriculture, Morogoro P.O. Box 30 007, Tanzania.
Amina A KinyogoriIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.
Walter S MagesaDepartment of Veterinay Medicine and Public Health, Sokoine University of Agriculture, Morogoro P.O. Box 30 007, Tanzania.ORCID 0000-0002-9671-8521
Aziza J SamsonDepartment of Veterinay Medicine and Public Health, Sokoine University of Agriculture, Morogoro P.O. Box 30 007, Tanzania.
Catherine MkindiIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.ORCID 0000-0001-8238-1940
Peter PaziaIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.
Feisal HassanIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.
Thabit A MbagaIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.
Robinson H MdegelaDepartment of Veterinay Medicine and Public Health, Sokoine University of Agriculture, Morogoro P.O. Box 30 007, Tanzania.ORCID 0000-0003-1498-8892
Honorati MasanjaIfakara Health Institute, Dar es Salaam P.O. Box 78 373, Tanzania.ORCID 0000-0002-3860-7348
Deborah CannonCenters for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, GA 30329, USA.
Aridith GibbonsCenters for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, GA 30329, USA.
John D KlenaCenters for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, GA 30329, USA.ORCID 0000-0001-9933-6193
Joel M MontgomeryCenters for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, GA 30329, USA.
Stuart T NicholCenters for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, GA 30329, USA.
Lucija JurisicOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Alexandre Tremeau-BravardOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Hezron NongaDepartment of Veterinay Medicine and Public Health, Sokoine University of Agriculture, Morogoro P.O. Box 30 007, Tanzania.
Jamie SebastianOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0001-8758-2530
Saba ZewdieOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Leah StrebOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Anna C FagreCenter for Vector-Borne Infectious Diseases, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-0969-5078
Nicholas A BergrenCenter for Vector-Borne Infectious Diseases, Colorado State University, Fort Collins, CO 80523, USA.
Daniel A HartmanCenter for Vector-Borne Infectious Diseases, Colorado State University, Fort Collins, CO 80523, USA.
David J WolkingOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0002-2518-5414
Rebekah C KadingCenter for Vector-Borne Infectious Diseases, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-4996-915X
Jonna A K MazetOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.
Brian H BirdOne Health Institute, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0001-8170-8710

Funding

VETERINARY STUDENT RESEARCH TRAINING PROGRAMT35RR007067 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI LLOYD, KC KENT · 2000 to 2011
$672k
Defense Threat Reduction Agency HDTRA1-14-1-0053NCRR NIH HHS T35 RR007067
6 · The paper itself

Abstract

Rift Valley fever (RVF) is a re-emerging vector-borne zoonotic disease that causes outbreaks in humans and animals across Africa. To better understand RVF at human-animal interfaces, a prospective longitudinal survey of people, livestock, and mosquitoes was conducted from 2016 to 2018, in two regions of Tanzania, with distinct climatic zones (Iringa and Morogoro). Molecular and serological tools for testing (RT-qPCR and IgM/IgG ELISA) for RVF virus (RVFV) were used to assess infection and exposure in people and animals. Mosquitoes were collected quarterly from 10 sentinel locations. In total, 1385 acutely febrile humans, 4449 livestock, and 3463 mosquito pools were tested. In humans, IgM seroprevalence was 3.75% (n = 52/1385), and overall seroprevalence (IgM and/or IgG positive) was 8.30% (n = 115/1385). People from Iringa had a higher exposure risk than those from Morogoro (aOR 2.63), and livestock owners had an increased risk compared to non-owners (aOR 2.51). In livestock, IgM seroprevalence was 1.09%, while overall seroprevalence was 10.11%. A total of 68.4% of herds had at least one seropositive animal. Sentinel animal follow-up revealed that the probability of seroconversion was significantly higher in Morogoro. Low-level RVFV RNA was detected in 8 human and 22 mosquito pools. These findings indicate active transmission among vectors, livestock, and people during the study period, highlighting the need for One Health surveillance approaches for RVFV and other arboviruses.

Indexed as

Disease OutbreaksLivestockRift Valley FeverRift Valley fever virusAdolescentAdultAnimalsAntibodies, ViralChildChild, PreschoolCulicidaeFemaleHumansImmunoglobulin GImmunoglobulin MLongitudinal StudiesAntibodies, ViralImmunoglobulin GImmunoglobulin Marbovirusesdisease surveillanceendemicepidemiologyhemorrhagic feverinter-epidemic transmissionOne HealthRift Valley feverTanzaniavirus transmissionzoonoses

Identifiers

PMID41157601
PMCPMC12567855

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.