Evidence map›Paper›PMID 41157598›Full record

ArticleViruses2025

Clade Ib Mpox in the Democratic Republic of the Congo (DRC): Clinical and Virological Report of the First Case in Kinshasa, the Capital City.

Franck Kasongo-Mulenda, Sylvie Lundi-Kizela, Sabrina Kalonji-Tshilomba, Deluxe Nsambayi-Lukusa, Mohesa Iteke, Richard Nkwembe-Mpileng, Abraham Muswibwe, Meris Matondo-Kuamfumu, Anguy Makaka, Junior Bulabula-Penge and 18 more

Abstract readCase Reports
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Franck Kasongo-MulendaInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Sylvie Lundi-KizelaService de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo.
Sabrina Kalonji-TshilombaService de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo.
Deluxe Nsambayi-LukusaService d'Ophtalmologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo.
Mohesa ItekeService de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo.
Richard Nkwembe-MpilengService de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo.
Abraham MuswibweService de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo.
Meris Matondo-KuamfumuInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Anguy MakakaService de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo.
Junior Bulabula-PengeInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.ORCID 0009-0009-4742-7419
Servet KinbonzaInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Emile MalembiHemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa P.O. Box 3088, Democratic Republic of the Congo.
Cris KacitaHemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa P.O. Box 3088, Democratic Republic of the Congo.
Robert Shongo LushimaHemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa P.O. Box 3088, Democratic Republic of the Congo.
Hélène Grace Otema-AkendaHemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa P.O. Box 3088, Democratic Republic of the Congo.
Emmanuel Lokilo-LofikoInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.ORCID 0000-0001-7581-9801
Elisabeth Pukuta-SimbuInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Adrienne Amuri-AzizaInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.ORCID 0000-0002-5516-0779
Eddy Kinganda-LusamakiInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Prince Akil-BandaliInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Ahidjo AyoubaTransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier (UM), Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), 34090 Montpellier, France.ORCID 0000-0002-5081-1632
Martine PeetersTransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier (UM), Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), 34090 Montpellier, France.
Eric DelaporteTransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses), Université de Montpellier (UM), Institut de Recherche pour le Développement (IRD), Institut National de Santé et de Recherche Médicale (INSERM), 34090 Montpellier, France.
Jean-Jacques Muyembe-TamfumInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Placide Mbala-KingebeniInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.
Antoine Nkuba-NdayeInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.ORCID 0000-0003-2850-7498
Véronique Kakiesse-MusumbaService de Dermatologie, Département de Spécialité, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa P.O. Box 127, Democratic Republic of the Congo.
Steve Ahuka-MundekeInstitut National de Recherche Biomédicale (INRB), Kinshasa P.O. Box 1197, Democratic Republic of the Congo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ongoing mpox clade Ib outbreak was first detected in the eastern Democratic Republic of Congo (DRC) and was associated with sexual transmission. It emerged in Kamituga, a mining city and spread rapidly in surrounding health zones and reached cities like Bukavu and Goma. Here, we describe the clinical, epidemiological, and virological characteristics of the first case of clade Ib in Kinshasa, the capital city in the western DRC. The case involved a young adult woman from Kinshasa who reported unprotected sexual contact with an occasional partner, a former friend, and subsequently developed genital lesions, including vesicles and pustules. These lesions evolved and spread to the entire body, including the limbs, eyes, and soles. The diagnosis was confirmed by PCR and sequencing allowed us to assign clade Ib. We show that infection with mpox clade Ib through sexual transmission can lead to limbal nodular keratoconjunctivitis and focal conjunctivitis as complications. Importantly, these results suggest that clade Ib may have been circulating silently in Kinshasa prior to the official declaration by the Ministry of Health. This also raises concerns about the potential risk of global spread, as is currently being observed. Further studies are needed to investigate whether subsequent outbreaks of clade Ib in Kinshasa may have emerged independently of introductions from Kivu, pointing to a more complex pattern of co-circulation that could define the mpox epidemic in the capital.

Indexed as

Mpox, MonkeypoxDemocratic Republic of the CongoDisease OutbreaksFemaleHumansPhylogenyYoung Adultclade Ib mpoxfirst casefollow-upkeratitisKinshasa

Identifiers

PMID41157598
PMCPMC12568009

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