Evidence map›Paper›PMID 41157597›Full record

ArticleViruses2025

In Vivo Characterization and Tissue Tropism of a Wild-Type Yellow Fever Virus Isolate from the 2017-2018 Brazilian Outbreak in C57BL/6 IFNAR1

Ana Luiza Campos Cruz, Natália Lima Pessoa, Ester Maria Paiva Silva, Sabrynna Brito Oliveira, Jéssica Pauline Coelho Souza, Samantha Stephany Fiuza Meneses Viegas, Anna Catarina Dias Soares Guimarães, Pedro Augusto Alves, Cintia Lopes de Brito Magalhães, Thomas P Monath and 5 more

Abstract read
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In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ana Luiza Campos CruzLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
Natália Lima PessoaLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-4284-2674
Ester Maria Paiva SilvaLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
Sabrynna Brito OliveiraLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0001-9303-4338
Jéssica Pauline Coelho SouzaLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
Samantha Stephany Fiuza Meneses ViegasLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
Anna Catarina Dias Soares GuimarãesLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
Pedro Augusto AlvesOswaldo Cruz Foundation (FIOCRUZ)-René Rachou Institute, Belo Horizonte 30190-002, MG, Brazil.ORCID 0000-0002-9659-5621
Cintia Lopes de Brito MagalhãesCrozet BioPharma LLC, Lexington, MA 02421, USA.
Thomas P MonathCrozet BioPharma LLC, Lexington, MA 02421, USA.
Olindo Assis Martins-FilhoOswaldo Cruz Foundation (FIOCRUZ)-René Rachou Institute, Belo Horizonte 30190-002, MG, Brazil.ORCID 0000-0002-5494-4889
Andréa Teixeira-CarvalhoOswaldo Cruz Foundation (FIOCRUZ)-René Rachou Institute, Belo Horizonte 30190-002, MG, Brazil.
A Desiree LaBeaudDepartment of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305, USA.
Nidia Esther Colquehuanca AriasLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
Betânia Paiva DrumondLaboratório de Vírus-Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-4049-4055

Funding

Yellow fever in Brazil: new insights on an old diseaseR01AI149614 · NIAID · STANFORD UNIVERSITY · PI FILHO, OLINDO ASSIS MARTINS, LABEAUD, ANGELLE DESIREE · 2020 to 2023
$609k
Conselho Nacional de Desenvolvimento Científico e Tecnológico 404192-2019-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001, and 88882.348380/2010-1Fundação de Amparo à Pesquisa do Estado de Minas Gerais 000NIAID NIH HHS R01 AI149614NIH HHS 1R01AI149614-19Secretaria de Estado de Saúde de Minas Gerais/Secretaria de Estado de Planejamento de Minas Gerais/Instituto René Rachou/Fundação Oswaldo Cruz 000
6 · The paper itself

Abstract

Yellow fever remains a significant public health concern in endemic regions of South America and Africa, where periodic outbreaks continue to challenge surveillance and control efforts. Despite the widespread use of vaccines and historical YFV strains in experimental settings, there is limited information on the pathogenic behavior of contemporary wild-type isolates in animal models. To address this gap, this study aimed to develop and characterize a murine model infected with a wild-type YFV strain isolated in 2018, from Brazil's largest sylvatic outbreak in decades. In this study, four-week-old male and female C57BL/6 IFNAR1

Indexed as

Receptor, Interferon alpha-betaViral TropismYellow FeverYellow fever virusAnimalsBrainBrazilDisease Models, AnimalDisease OutbreaksFemaleMaleMiceMice, Inbred C57BLMice, KnockoutViral LoadIfnar1 protein, mouseReceptor, Interferon alpha-betabrazilian isolateC57BL/6 IFNAR1−/− micefemalemalewild-type YFyellow fever

Identifiers

PMID41157597
PMCPMC12567742

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.