Evidence map›Paper›PMID 41157576›Full record

ArticleViruses2025

Human Papillomavirus Prevalence in the Prostate and Seminal Vesicles: Does This Virus Have an Etiological Role in the Development of Prostate Cancer?

Rei Shinzawa, Kazuyoshi Shigehara, Hiroki Nakata, Shingo Takada, Kotaro Fukukawa, Yuki Kato, Tomomi Nakagawa, Shohei Kawaguchi, Kouji Izumi, Atsushi Mizokami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rei ShinzawaIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.ORCID 0009-0002-1781-2817
Kazuyoshi ShigeharaIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.ORCID 0000-0002-2118-9135
Hiroki NakataIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.ORCID 0000-0002-5532-7356
Shingo TakadaIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.
Kotaro FukukawaIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.
Yuki KatoIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.ORCID 0000-0002-1833-5381
Tomomi NakagawaIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.
Shohei KawaguchiDepartment of Urology, Kanazawa Medical Center, Kanazawa 920-8650, Japan.
Kouji IzumiIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.ORCID 0000-0002-8480-9100
Atsushi MizokamiIntegrative Cancer Therapy and Urology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-0934, Japan.ORCID 0000-0002-5643-2182

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV) is common in both sexes and is also detected in male urine and semen. However, its exact origin and its etiological role in the male genital tract remain unclear. A total of 157 formalin-fixed paraffin-embedded tissues from 156 primary prostate cancer lesions and one metastatic lesion were analyzed. HPV-DNA was detected using a nested PCR, and HPV genotyping was performed using flow-through hybridization for positive cases. In situ hybridization (ISH) was used to localize HPV-DNA, whereas HPV-E6/E7 mRNA ISH and p16

Indexed as

PapillomaviridaePapillomavirus InfectionsProstateProstatic NeoplasmsSeminal VesiclesAgedAged, 80 and overDNA, ViralGenotypeHuman Papillomavirus VirusesHumansMaleMiddle AgedPrevalenceDNA, ViralE6/E7 mRNAp16papillomavirusprostate cancerseminal vesicle

Identifiers

PMID41157576
PMCPMC12567726

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.