A Highly Sensitive Silicon Nanowire Array Field Effect Transistor Biosensor for Detecting HBV-DNA and AFP.

Peng Sun, Mingbin Liu, Yongxin Zhang, Chaoran Liu, Xun Yang

Abstract read

In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

From Device-Level Implementation to In-Sensor Computing in Memristive-Device-Based Biosensors: A Review.Biosensors · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peng SunSchool of Information Technology, Luoyang Normal University, Luoyang 471934, China.

Mingbin LiuSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.

Yongxin ZhangSchool of Information Technology, Luoyang Normal University, Luoyang 471934, China.

Chaoran LiuMinistry of Education Engineering Research Center of Smart Microsensors and Microsystems, College of Elecctronics and Information, Hangzhou Dianzi University, Hangzhou 310018, China.ORCID 0000-0002-6896-328X

Xun YangSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.

Funding

Key Research and Development Special Project of Henan Province 251111320500Key Research Projects of Higher Education Institutions in Henan Province 24A510010Natural Science Foundation of Henan Province 242300420692Science and Technology Research Project of Henan Province 252102210207

6 · The paper itself

Abstract

Chronic hepatitis B poses a serious threat to human health and life, and early diagnosis is essential to improving patient cure rates. Hepatitis B virus (HBV) and Alpha-fetoprotein (AFP) are two key biomarkers for diagnosing chronic hepatitis B. In this study, we propose a silicon nanowire array field effect transistor (SiNW-array FET) biosensor that enables highly sensitive, real-time, and low-cost joint detection of both HBV and AFP. The SiNW-array FET is fabricated using traditional micro-nano fabrication techniques such as self-limiting oxidation and anisotropic etching, and its morphology and electrical properties were tested. The results show that the diameters of the fabricated silicon nanowires (SiNWs) are uniform and the SiNW-array FET exhibits a strong output signal and high signal-to-noise ratio. Through specific chemical modification on the surface of SiNWs, the SiNW-array FET is highly sensitive and specific to HBV-DNA fragments and AFP, with ultralow detection limits of 0.1 fM (HBV-DNA) and 0.1 fg/mL (AFP). The detection curve of the SiNW-array FET exhibits good linearity within the HBV-DNA concentration range of 0.1 fM to 100 pM and AFP concentration range of 0.1 fg/mL to 1000 pg/mL. More importantly, the device could also detect HBV-DNA successfully in serum samples, laying a solid foundation for the highly sensitive clinical detection of chronic hepatitis B.

Indexed as

alpha-FetoproteinsBiosensing TechniquesDNA, ViralHepatitis B virusNanowiresSiliconHumansLimit of DetectionTransistors, Electronicalpha-FetoproteinsDNA, ViralSiliconhepatitis B virushighly sensitivejoint detectionSiNW-array FET

Identifiers

PMID41157439

DOI10.3390/s25206385

PMCPMC12567904

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.