ArticleLife (Basel, Switzerland)2025
Design, Structural Stability, Membrane Binding, and Antibacterial Activity of Novel Antimicrobial Peptides Derived from Wuchuanin-A1.
Rizki A Putri, Ahmad Habibie, Prajnaparamita Dhar, Krzysztof Kuczera, Respati Tri Swasono, Muhammad Saifur Rohman, Tri Joko Raharjo, Teruna J Siahaan
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In one paragraphArticle in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
8 authors.
Rizki A PutriDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
Ahmad HabibieDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
Prajnaparamita DharDepartment of Chemical and Petroleum Engineering, School of Engineering, The University of Kansas, Eaton Hall, 1520 W 15th St, Lawrence, KS 66045, USA.ORCID 0000-0002-5821-5253 Krzysztof KuczeraDepartment of Chemistry, College of Liberal Arts & Sciences, The University of Kansas, Gray-Little Hall, 1567 Irving Hill Rd, Lawrence, KS 66045, USA.ORCID 0000-0003-2358-1349 Respati Tri SwasonoDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
Muhammad Saifur RohmanDepartment of Agricultural Microbiology, Universitas Gadjah Mada, Jl Flora, Kompleks Bulaksumur, UGM, Yogyakarta 55281, Indonesia.ORCID 0000-0002-7764-9778 Tri Joko RaharjoDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.ORCID 0000-0003-0615-5241 Teruna J SiahaanDepartment of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Simons Laboratories, 2095 Constant Ave., Lawrence, KS 66045, USA.ORCID 0000-0001-7250-0627 Funding
Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9MReshaping ApoE4 and Alzheimer's Brains with ApoE2R01AG071682 · NIA · UNIVERSITY OF KANSAS LAWRENCE · PI TERUNA J. SIAHAAN, Liqin Zhao · 2022 to 2026
$3.4MA Novel Method to Enhance Drug Delivery to the BrainR01AG082273 · NIA · UNIVERSITY OF KANSAS LAWRENCE · PI KRZYSZTOF KUCZERA, TERUNA J. SIAHAAN · 2024 to 2026
$1.4MAVIII HD 400 NMR spectrometer to replace existing DRX 400S10OD016360 · OD · UNIVERSITY OF KANSAS LAWRENCE · PI DOUGLAS, JUSTIN TRIGALET · 2014 to 2014
$297kNIA NIH HHS R01 AG071682NIA NIH HHS R01 AG082273NIGMS NIH HHS P20 GM113117NIH HHS 1P01GM113117-02NIH HHS 1R01AG071682-05NIH HHS 1R01AG082273-05NIH HHS S10 OD016360NIH Office of Director S10OD016360PKPI Sandwich-like program 165.27/E4.4/KU/2023PMDSU Research Grant 018/E5/PG.02.00.PL/2023; 2194/UN1/DITLIT/Dit Lit/PT.01.03/2023
6 · The paper itselfAbstract
Antibiotic resistance is a major health problem globally, highlighting the need for alternative antimicrobials that may potentially reduce the emergence of resistance compared to conventional antibiotics. Antimicrobial peptides (AMPs) are promising candidates because of their broad-spectrum activity. In this study, we designed three derivatives (i.e., Analog-1, -2, and -3) of the native peptide, Wuchuanin-A1, for improving their antibacterial activity against
Indexed as
amphipathic helixantibacterialCD spectroscopymembrane disruptionmolecular dynamics simulationsNMRpeptide modificationα-helical peptides
Identifiers
PMID41157240
PMCPMC12565435
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