Evidence map›Paper›PMID 41157224›Full record

ArticleLife (Basel, Switzerland)2025

Low DLCO Can Provide Insights into Treatment Response in PAH Patients Irrespective of the Reason for Its Decrease.

Effrosyni Dima, Stylianos E Orfanos, Vasileios Grigoropoulos, Dimitra Fasfali, Athina Mpatsouli, Natalia P Zimpounoumi-Keratsa, Panagioula Niarchou, Athanasia Megarisiotou, Efstathia Prappa, Sotirios Xydonas and 3 more

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Effrosyni DimaPulmonary Hypertension Center of "Evangelismos" Hospital and 1st Department of Critical Care Medicine and Pulmonary Services, Medical School, National and Kapodistrian University of Athens, "Evangelismos" Hospital, 10676 Athens, Greece.
Stylianos E OrfanosCritical Care, Medical School, National and Kapodistrian University of Athens, 10676 Athens, Greece.
Vasileios GrigoropoulosPulmonary Hypertension Center of "Evangelismos" Hospital and 1st Department of Critical Care Medicine and Pulmonary Services, Medical School, National and Kapodistrian University of Athens, "Evangelismos" Hospital, 10676 Athens, Greece.
Dimitra FasfaliPulmonary Hypertension Center of "Evangelismos" Hospital and 1st Department of Critical Care Medicine and Pulmonary Services, Medical School, National and Kapodistrian University of Athens, "Evangelismos" Hospital, 10676 Athens, Greece.
Athina MpatsouliPulmonary Hypertension Center of "Evangelismos" Hospital, and Cardiology Department, "Evangelismos" Hospital, 10676 Athens, Greece.
Natalia P Zimpounoumi-KeratsaPulmonary Hypertension Center of "Evangelismos" Hospital, and Cardiology Department, "Evangelismos" Hospital, 10676 Athens, Greece.
Panagioula NiarchouPulmonary Hypertension Center of "Evangelismos" Hospital, and Cardiology Department, "Evangelismos" Hospital, 10676 Athens, Greece.ORCID 0000-0002-3853-8186
Athanasia MegarisiotouPulmonary Hypertension Center of "Evangelismos" Hospital, and Cardiology Department, "Evangelismos" Hospital, 10676 Athens, Greece.
Efstathia PrappaPulmonary Hypertension Center of "Evangelismos" Hospital, and Cardiology Department, "Evangelismos" Hospital, 10676 Athens, Greece.
Sotirios XydonasPulmonary Hypertension Center of "Evangelismos" Hospital, and Cardiology Department, "Evangelismos" Hospital, 10676 Athens, Greece.ORCID 0009-0003-7555-4577
Anastasia KotanidouPulmonary Hypertension Center of "Evangelismos" Hospital and 1st Department of Critical Care Medicine and Pulmonary Services, Medical School, National and Kapodistrian University of Athens, "Evangelismos" Hospital, 10676 Athens, Greece.ORCID 0000-0002-2508-500X
Ioanna DimopoulouPulmonary Hypertension Center of "Evangelismos" Hospital and 1st Department of Critical Care Medicine and Pulmonary Services, Medical School, National and Kapodistrian University of Athens, "Evangelismos" Hospital, 10676 Athens, Greece.
Anastasia AnthiPulmonary Hypertension Center of "Evangelismos" Hospital and 1st Department of Critical Care Medicine and Pulmonary Services, Medical School, National and Kapodistrian University of Athens, "Evangelismos" Hospital, 10676 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Group 1 of PAH patients encompasses patients with a diverse underlying etiological condition, having histological modifications that can affect gas exchange across the alveolar-capillary membrane, as reflected by decreased DLCO. Values of DLCO did not identify the exact reason for their decrease, but they can provide insights into the underlying pathobiology and prognosis of PAH patients. Our aim was to explore whether PAH patients with low DLCO constitute a different subpopulation and describe their characteristics and response to treatment. A total of 69 PAH patients were studied retrospectively and divided into two groups:

Indexed as

clinical characteristicsDLCOPAHphenotypetreatment

Identifiers

PMID41157224
PMCPMC12565467

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.