ArticleMolecules (Basel, Switzerland)2025
Improved Synthesis of 5-Nitrohomovanillic Acid and 6-Nitrohomovanillic Acid as Probes for Metabolism Studies of Endothelium-Derived Dopamines: Identification in Human Amniotic Fluid.
Rosa Sparaco, Pierfrancesco Cinque, Antonia Scognamiglio, Stefania Vertuccio, Giuseppe Caliendo, Ferdinando Fiorino, Angela Corvino, Elisa Magli, Elisa Perissutti, Vincenzo Santagada and 7 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
17 authors.
Rosa SparacoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0009-0003-4221-5560 Pierfrancesco CinqueDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Antonia ScognamiglioDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-4282-2788 Stefania VertuccioDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0009-0004-0542-132X Giuseppe CaliendoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Ferdinando FiorinoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-7357-5751 Angela CorvinoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-0617-156X Elisa MagliDepartment of Public Health, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0002-9930-9467 Elisa PerissuttiDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-1754-1191 Vincenzo SantagadaDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Beatrice SeverinoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-3887-8869 Giorgia AndreozziDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Paolo LucianoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Carmela Dell'AversanoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-8337-3029 Alex Henrique MillerDepartment of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-888, SP, Brazil.ORCID 0000-0001-8269-850X Gilberto De NucciDepartment of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-888, SP, Brazil.ORCID 0000-0002-4346-7941 Francesco FrecenteseDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0001-8821-2937 Funding
Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/16805-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/08067-1Tabled Agreement regarding Cultural and Scientific Collaboration between the University of Naples Federico II and Facultade Sao Leopoldo Mandic n.a.
6 · The paper itselfAbstract
6-Nitrodopamine is an endogenous catecholamine responsible for numerous biological activities. Here, an improved method for the synthesis of both 6-nitrohomovanillic acid (6-NHVA) and its regioisomer 5-nitrohomovanillic acid (5-NHVA) is reported. The developed one-step synthetic procedures ensured the efficient preparation of the target compounds in good yields. Comprehensive structural characterization was achieved through one- and two-dimensional NMR studies and by high-resolution mass spectrometry (HR-MS/MS). The presence of both substances was identified in human amniotic fluid by LC-MS/MS.
Indexed as
Amniotic FluidDopamineHomovanillic AcidHumansMolecular StructureTandem Mass SpectrometryDopamineHomovanillic Acid5-nitrohomovanillic acid6-nitrodopanine6-nitrohomovanillic acidhigh-resolution mass spectrometryhuman amniotic fluidNMR
Identifiers
PMID41157112
PMCPMC12566566
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