Evidence map›Paper›PMID 41156809›Full record

ArticleMicroorganisms2025

Differential Patterns of Gut and Oral Microbiomes in Hispanic Individuals with Cognitive Impairment.

Yannick N Wadop, Erin L Vasquez, Julia J Mathews, Jazmyn A S Muhammad, Rosa Pirela Mavarez, Claudia L Satizabal, Mitzi M Gonzales, Jeremy Tanner, Gladys Maestre, Alfred N Fonteh and 3 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yannick N WadopGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-8955-1874
Erin L VasquezGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Julia J MathewsGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Jazmyn A S MuhammadGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Rosa Pirela MavarezDepartment of Neurosciences and Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX 78539, USA.ORCID 0000-0002-9019-2768
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-1115-4430
Mitzi M GonzalesGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Jeremy TannerGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-9828-1776
Gladys MaestreDepartment of Neurosciences and Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX 78539, USA.
Alfred N FontehNeurosciences Department, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.ORCID 0000-0003-4860-5749
Sudha SeshadriGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Tiffany F KautzGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-7680-4708
Bernard FongangGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-8161-1553

Funding

South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
Rio Grande Valley Alzheimer's Resource Center for Minority Aging Research: Partnerships for ProgressP30AG059305 · NIA · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI Eron Grant Manusov · 2018 to 2026
$5.8M
Multiethnic Validation of VCID biomarkers in South TexasUF1NS125513 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SATIZABAL, CLAUDIA L · 2021 to 2021
$2.4M
Sulfatide deficiency: A novel mechanism leading to reactive astrogliosis in aging and Alzheimer’s diseaseRF1AG061729 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HAN, XIANLIN · 2021 to 2021
$1.9M
ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model SystemsU01AG052409 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2016 to 2020
$1.6M
Building Unique Infrastructure for Large-scale Dementia research in French-Speaking Africa (BUILD-FSA) ProjectUG3AG090675 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Bernard Fongang, Alfred Kongnyu Njamnshi · 2025 to 2026
$992k
Delineating the role of the gut microbiota and its derived metabolites in the development of dementia in multi-ethnic populationsK01NS126489 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Bernard Fongang · 2023 to 2026
$882k
Bridging Gaps to Translate Plasma Alzheimer's Disease Biomarkers to Diverse PopulationsK08AG090815 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jeremy Adam Tanner · 2025 to 2026
$326k
NIA NIH HHS 5P30AG059305-03NIA NIH HHS 5U01AG052409-04NIA NIH HHS K08 AG090815NIA NIH HHS P30 AG059305NIA NIH HHS P30 AG066546NIA NIH HHS RF1 AG061729NIA NIH HHS RF1AG061729A1NIA NIH HHS U01 AG052409NIA NIH HHS UG3 AG090675NINDS NIH HHS K01 NS126489NINDS NIH HHS NS017950, UF1NS125513, K01NS126489NINDS NIH HHS R01 NS017950NINDS NIH HHS UF1 NS125513
6 · The paper itself

Abstract

Alterations in both oral and gut microbiomes have been associated with Alzheimer's disease and related dementia (ADRD). While extensive research has focused on the role of gut dysbiosis in ADRD, the contribution of the oral microbiome remains relatively understudied. This study aims to evaluate distinct patterns and potential synergistic effects of oral and gut microbiomes in a cohort of predominantly Hispanic individuals with cognitive impairment (CI) and without cognitive impairment (NC). We conducted 16S rRNA gene sequencing on stool and saliva samples from 32 participants (17 CI, 15 NC; 62.5% female, mean age = 70.4 ± 6.2 years) recruited in San Antonio, Texas, USA. Differential abundance analysis evaluated taxa with significant differences between both groups. While diversity metrics showed no significant differences between CI and NC groups, differential abundance analysis revealed an increased presence of oral genera such as

Indexed as

Alzheimer’s diseaseanti-inflammatory propertiescognitive impairmentgut microbiomeHispanicsKEGG pathwaysoral microbiome

Identifiers

PMID41156809
PMCPMC12566222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.