Evidence map›Paper›PMID 41156769›Full record

ArticleMicroorganisms2025

Infectious Keratitis: A Tertiary Center's Approach to Diagnosis, Management, and Enhanced Outcomes Through Microbiological Analysis.

Antonio Moramarco, Federico Cassini, Natalie di Geronimo, Giovanni Zanini, Michele Potenza, Matteo Farnè, Viviana Schisa, Erica De Carolis, Margherita Ortalli, Piera Versura and 2 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antonio MoramarcoOphthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-2847-1691
Federico CassiniOphthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0009-0004-4785-107X
Natalie di GeronimoIRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-9359-8608
Giovanni ZaniniOphthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Michele PotenzaOphthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0009-0007-6559-4996
Matteo FarnèDepartment of Statistical Sciences "Paolo Fortunati", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-2403-6599
Viviana SchisaDepartment of Statistical Sciences "Paolo Fortunati", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
Erica De CarolisDepartment of Statistical Sciences "Paolo Fortunati", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0009-0005-0645-2977
Margherita OrtalliDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0001-5447-8817
Piera VersuraOphthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-2951-5337
Tiziana LazzarottoDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-3093-363X
Luigi FontanaOphthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-3877-0417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe study aimed to assess the diagnostic and therapeutic management of infectious keratitis at a tertiary referral center, focusing on how microbiological analysis influences clinical outcomes.

methodsA retrospective review was conducted on 220 patients (221 eyes) with infectious keratitis treated between November 2021 and January 2025. Data collected included clinical presentation, microbiological findings, treatment approaches, and outcomes. Statistical analyses examined the relationships between microbiological results, improvements in visual acuity, and the need for rescue surgery.

resultsBacterial keratitis accounted for 64% of cases, followed by viral (20%), fungal (13%), and Acanthamoeba (3%). Microbiological testing was performed in 107 cases, with a culture positivity rate of 75.7%. Positive microbiological findings were significantly associated with better visual acuity (

conclusionEarly referral and targeted therapy are essential for optimizing prognosis. The use of contact lenses and cases of ocular trauma should prompt early diagnostic sampling.

Indexed as

Acanthamoeba keratitisbacterial keratitiscorneal infectionsepidemiologyfungal keratitismicrobial keratitisophthalmologyviral keratitis

Identifiers

PMID41156769
PMCPMC12565946

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.