Evidence map›Paper›PMID 41156762›Full record

ReviewMicroorganisms2025

Associations Between the Gut Microbiome and Outcomes in Autologous Stem Cell Transplantation: A Systematic Review.

Ema Pitts, Brian Grainger, Dean McKenzie, Salvatore Fiorenza

Abstract readReview
In one paragraph

Review in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ema PittsEpworth Centre for Immunotherapies and Snowdome Laboratories, Department of Molecular Oncology and Cancer Immunology, Epworth HealthCare, Richmond, VIC 3002, Australia.
Brian GraingerEpworth Centre for Immunotherapies and Snowdome Laboratories, Department of Molecular Oncology and Cancer Immunology, Epworth HealthCare, Richmond, VIC 3002, Australia.ORCID 0000-0002-1067-9315
Dean McKenzieOffice for Research, Epworth HealthCare, Richmond, VIC 3002, Australia.
Salvatore FiorenzaEpworth Centre for Immunotherapies and Snowdome Laboratories, Department of Molecular Oncology and Cancer Immunology, Epworth HealthCare, Richmond, VIC 3002, Australia.ORCID 0000-0003-4432-2215

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous stem cell transplantation (ASCT) is the standard frontline consolidation strategy in fit, eligible patients with chemosensitive multiple myeloma, and it also serves as salvage option in other haematological malignancies, such as diffuse large B cell lymphoma. Moreover, ASCT is known to disrupt the gut microbiome (GM), and the impact on clinical outcomes has been understudied. The aim of this review is to examine the associations between the GM and outcomes in patients undergoing ASCT. Using the PRISMA 2020 guidelines for systematic reviews and meta-analyses, a total of 11 articles were included in this review, comprising both observational studies (cohort studies, case-control studies) and interventional trials (randomised controlled trials). Consistent findings included a notable decrease in beneficial bacteria, including

Indexed as

autologous stem cell transplantationgut microbiomeimmune reconstitutioninfectious complicationsintestinal floramultiple myelomaoutcomesoverall survivalprogression-free survivalrelapse

Identifiers

PMID41156762
PMCPMC12566328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.