Evidence map›Paper›PMID 41156760›Full record

ArticleMicroorganisms2025

Elimination of Airborne Microorganisms Using Compressive Heating Air Sterilization Technology (CHAST): Laboratory and Nursing Home Setting.

Pritha Sharma, Supriya Mahajan, Gene D Morse, Rolanda L Ward, Satish Sharma, Stanley A Schwartz, Ravikumar Aalinkeel

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Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Pritha SharmaDepartment of Medicine, Yale New Haven Health, New Haven, CT 06610, USA.
Supriya MahajanDivision of Allergy, Immunology and Rheumatology, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical and Translational Research Center, 875 Ellicott St., Buffalo, NY 14203, USA.ORCID 0000-0002-5298-6962
Gene D MorseCenter for Integrated Global Biomedical Sciences, Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Rolanda L WardDepartment of Social Work, Niagara University, Niagara Falls, NY 14109, USA.
Satish SharmaDepartment of Urology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical and Translational Research Center, 875 Ellicott St., Buffalo, NY 14203, USA.
Stanley A SchwartzDivision of Allergy, Immunology and Rheumatology, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical and Translational Research Center, 875 Ellicott St., Buffalo, NY 14203, USA.ORCID 0000-0002-8664-1380
Ravikumar AalinkeelDivision of Allergy, Immunology and Rheumatology, Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical and Translational Research Center, 875 Ellicott St., Buffalo, NY 14203, USA.ORCID 0000-0003-0883-4061

Funding

This work was supported in part by the City of Niagara Falls and by You First Group of Companies, Cheektowaga, NY 14205, who provided all requirements for the implementation of CHAST technology NIL
6 · The paper itself

Abstract

backgroundAirborne transmission of bacteria, viruses, and fungal spores poses a major threat in enclosed settings, particularly nursing homes where residents are highly vulnerable. Compressive Heating Air Sterilization Technology (CHAST) applies compressive heating to inactivate microorganisms without reliance on filtration or chemicals.

methodsCHAST efficacy was evaluated in laboratory and deployed for a feasibility and performance validation study of air sterilization in a nursing home environment. Laboratory studies tested prototypes (300-5000 CFM; 220-247 °C) against aerosolized surrogates including

resultsLaboratory testing demonstrated consistent microbial inactivation, with most prototypes achieving > 6-log (99.9999%) reductions across bacterial spores, vegetative bacteria, and viruses. A 5000 CFM prototype achieved > 7-log (99.99999%) elimination of

conclusionCHAST reproducibly and scalably inactivated airborne bacteria, viruses, and fungi under laboratory and feasibility field studies, supporting its potential as a chemical-free strategy to improve infection control and indoor air quality in healthcare facilities.

Indexed as

air sterilizationcompressive heatinghealthcare associated infectionlong-term care facilityvolatile organic compounds

Identifiers

PMID41156760
PMCPMC12566561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.