Evidence map›Paper›PMID 41156731›Full record

ArticleMicroorganisms2025

Tissue Expression of NGF in Skin Lesions of HIV-Coinfected and Non-Coinfected Leprosy Patients and Its Relationship with Leprosy Neural Damage.

Marília Brasil Xavier, Lucas Dos Santos Fontes, Mariana Garcia Borges do Nascimento, Simone Rodrigues Dos Passos, Débora Pinheiro Xavier, Larissa Dos Santos Alcantara, Elza Baía de Brito, Cláudia Maria de Castro Gomes, Carlos Eduardo Pereira Corbett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marília Brasil XavierResearch Laboratory in Tropical Dermatology and Endemic Diseases, Nucleus of Tropical Medicine, Federal University of Pará, Belém 66055-240, Brazil.
Lucas Dos Santos FontesResearch Laboratory in Tropical Dermatology and Endemic Diseases, Nucleus of Tropical Medicine, Federal University of Pará, Belém 66055-240, Brazil.ORCID 0000-0002-0588-4461
Mariana Garcia Borges do NascimentoResearch Laboratory in Tropical Dermatology and Endemic Diseases, Nucleus of Tropical Medicine, Federal University of Pará, Belém 66055-240, Brazil.
Simone Rodrigues Dos PassosResearch Laboratory in Tropical Dermatology and Endemic Diseases, Nucleus of Tropical Medicine, Federal University of Pará, Belém 66055-240, Brazil.
Débora Pinheiro XavierResearch Laboratory in Tropical Dermatology and Endemic Diseases, Nucleus of Tropical Medicine, Federal University of Pará, Belém 66055-240, Brazil.ORCID 0000-0002-9807-3552
Larissa Dos Santos AlcantaraInfectious Diseases Pathology Laboratory (LIM50), Pathology Department, Medical School, São Paulo University, São Paulo 01246-903, Brazil.
Elza Baía de BritoResearch Laboratory in Tropical Dermatology and Endemic Diseases, Nucleus of Tropical Medicine, Federal University of Pará, Belém 66055-240, Brazil.
Cláudia Maria de Castro GomesInfectious Diseases Pathology Laboratory (LIM50), Pathology Department, Medical School, São Paulo University, São Paulo 01246-903, Brazil.ORCID 0000-0001-9909-9466
Carlos Eduardo Pereira CorbettInfectious Diseases Pathology Laboratory (LIM50), Pathology Department, Medical School, São Paulo University, São Paulo 01246-903, Brazil.

Funding

Amazon Foundation to Support Studies and Research (Fapespa) 2CSRD VA 1Federal University of Pará (UFPA) 2São Paulo Research Foundation (FAPESP) 2014/50315-0
6 · The paper itself

Abstract

Leprosy remains a significant public health issue, particularly due to its neuropathic consequences, which affect sensory, motor, and autonomic functions, leading to severe disabilities. HIV/AIDS, another major public health concern, overlaps geographically with leprosy and is also associated with peripheral neuropathies, complicating the management of co-infected patients. Understanding how Nerve Growth Factor (NGF) is regulated in leprosy and HIV-leprosy co-infection may contribute to immunomodulatory treatments and neuroimmune response control. A cross-sectional study evaluated NGF tissue expression using immunohistochemistry in 47 HIV/leprosy co-infected patients and 61 leprosy-only patients. The co-infected group had a higher incidence of neuritis (40.4%) and a prevalence of exclusively reversal reactions. However, the occurrence of neuritis was not associated with higher expression of NGF in the tissue. Leprosy reactions were more prevalent in non-co-infected patients with multibacillary forms (50%). Multibacillary forms in both groups of patients showed higher cellular expression of NGF, with a greater tendency for higher NGF expression in non-co-infected multibacillary patients (

Indexed as

acquired immunodeficiency syndromeco-infectionHIVimmunohistochemistryleprosynerve growth factorneuritis

Identifiers

PMID41156731
PMCPMC12566393

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.