Evidence map›Paper›PMID 41156610›Full record

ArticlePathogens (Basel, Switzerland)2025

Antifungal Activity of 8-Hydroxyquinoline Derivatives Against

Maria Eduarda Krummenauer, Matheus da Silva Camargo, Caroline de Bem Gentz, Marcela Silva Lopes, Letícia Feliciani da Luz, Danielle da Silva Trentin, Belisa Ávila Rodrigues, Karine Rigon Zimmer, Saulo Fernandes de Andrade, Marilene Henning Vainstein

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Design and mechanistic evaluation of chalcone-quinoline-triazole hybrids as antifungal CYP51 inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  2. Flavonoids as a Potential Antifungal Alternative AgainstJournal of fungi (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maria Eduarda KrummenauerCentro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, Porto Alegre 91501-970, RS, Brazil.ORCID 0000-0003-2371-296X
Matheus da Silva CamargoCentro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, Porto Alegre 91501-970, RS, Brazil.ORCID 0000-0002-8230-6702
Caroline de Bem GentzFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil.ORCID 0000-0002-8864-4470
Marcela Silva LopesFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil.
Letícia Feliciani da LuzPrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre-UFCSPA, Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0002-4746-7826
Danielle da Silva TrentinPrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre-UFCSPA, Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0002-8622-1052
Belisa Ávila RodriguesPrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre-UFCSPA, Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0003-0924-0206
Karine Rigon ZimmerPrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre-UFCSPA, Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0002-7962-7353
Saulo Fernandes de AndradePrograma de Pós-Graduação em Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre 91500-970, RS, Brazil.ORCID 0000-0003-2873-7939
Marilene Henning VainsteinCentro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, Porto Alegre 91501-970, RS, Brazil.ORCID 0000-0002-3914-2300

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307104/2025-7Conselho Nacional de Desenvolvimento Científico e Tecnológico 313620/2021-0; 308617/2021-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 406112/2021-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Apoio à Pesquisa do Estado do Rio Grande do Sul 22/2551-0000396-6The National Institute of Science and Technology INCT Funvir 405934/2022-0
6 · The paper itself

Abstract

Invasive fungal infections and the emergence of antifungal resistance pose significant challenges to public health. This study evaluates the antifungal activity of two 8-hydroxyquinoline derivatives, PH265 and PH276, against

Indexed as

Antifungal AgentsCandidaCandida aurisCryptococcus gattiiCryptococcus neoformansOxyquinolineAnimalsBiofilmsCaenorhabditis elegansDrug SynergismFluconazoleMicrobial Sensitivity TestsAntifungal AgentsFluconazoleOxyquinoline8-hydroxyquinolineantifungalsC. aurisC. haemuloniiCryptococcus spp.

Identifiers

PMID41156610
PMCPMC12567370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.