Evidence map›Paper›PMID 41156336›Full record

ArticleMicromachines2025

High-Performance Silicon Nanowire Array Biosensor for Combined Detection of Colorectal Cancer Biomarkers.

Jiaye Zeng, Mingbin Liu, Xin Chen, Jintao Yi, Wenhe Liu, Xinjian Qu, Chaoran Liu, Serestina Viriri, Guangguang Yang, Xun Yang and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jiaye ZengSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.
Mingbin LiuSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.
Xin ChenSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.
Jintao YiSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.
Wenhe LiuSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.
Xinjian QuSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.
Chaoran LiuMinistry of Education Engineering Research Center of Smart Microsensors and Microsystems, College of Electronics and Information, Hangzhou Dianzi University, Hangzhou 310018, China.ORCID 0000-0002-6896-328X
Serestina ViririSchool of Mathematics, Statistics & Computer Science, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0002-2850-8645
Guangguang YangSchool of Electronic and Information Engineering, Foshan University, Foshan 528000, China.
Xun YangSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.
Weichao YangSchool of Electronic and Information Engineering, China West Normal University, Nanchong 637002, China.

Funding

the Key Laboratory of Detection and Application of Space Effect in Southwest Sichuan at Leshan Normal University, Education Department of Sichuan Province No. ZDXM202401004
6 · The paper itself

Abstract

This study presents a high-performance silicon nanowire (SiNW) array biosensor for the combined detection of two key colorectal cancer (CRC) biomarkers: circulating tumor DNA (ctDNA) and carcinoembryonic antigen (CEA). The device was fabricated using conventional micromachining techniques, enabling the integration of dual SiNW arrays on a single chip with precise control over structure and surface functionalization. Specific probe DNA and anti-CEA antibodies were immobilized on distinct array regions to facilitate targeted binding. The biosensor demonstrated exceptional performance, achieving an ultralow detection limit of 10 aM for ctDNA with a linear range from 0.1 fM to 10 pM, and a sensitivity of 1 fg/mL for CEA. It exhibited high selectivity against interfering substances, including single-base mismatched DNA and non-specific proteins, and maintained robust performance in human serum samples. The platform offers a scalable, label-free, and real-time detection solution with significant potential for application in early CRC screening and personalized medicine.

Indexed as

colorectal cancer biomarkerscombined detectionhighly controllablelow costsilicon nanowire arrays

Identifiers

PMID41156336
PMCPMC12565856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.